Antifungal agents

Question 1

Infections caused by yeasts, molds etc that can invade epithelial tissue

Answer 1

Fungal infections

Question 2

Caused by dermatophytes

Incidence rate is high

Answer 2

Superficial fungal infxn

Question 3

Transmitted frm one host to another

Answer 3

Deep-seated mycoses

Question 4

Caused by inhalation of spores

Answer 4

Systemic fungal infxns

Question 5

Can cause fungal pneumonia

Answer 5

Systemic fungal infxns

Question 6

Pneumonia cannot be transmitted from human to human

Answer 6

Fungal pneumonia

Question 7

Result of random screening

Answer 7

Allylamines

Question 8

Interfere early step of ergosterol biosynthesis

Answer 8

Allylamines

Question 9

Inhibition of squalene epoxidase

Answer 9

Allylamines

Question 10

Epoxidation causes

Answer 10

Ring opening

Question 11

Ring opening aka

Answer 11

Squalene zipper

Question 12

Ring opening causes

Answer 12

Ergosterol biosynthesis

Question 13

Static against pathogenic yeast

Cidal against dermatophytes & filamentous fungi

Answer 13

Allylamines

Question 14

Naftifine HCl brand name

Answer 14

Naftifin

Question 15

1% cream/gel

Used topically against ringworm, athlete’s foot & jock itch

Answer 15

Naftifine HCl

Question 16

Terbinafine HCl brand name

Answer 16

Lamisil

Question 17

Use is same as Naftifine but active against onychomycosis

Answer 17

Terbinafine HCl

Question 18

Tolnaftate brand name

Answer 18

Tinactine

Question 19

Tioester of B-naphthol

Inhibits squalene epoxidase (-cidal)

Answer 19

Tolnaftate