Autonomic Phys Flashcards
1
Q
Nm
A
Skeletal muscle NMJ; ligand-gated ionotropic
2
Q
Nn
A
CNS postganglionic cell body, dendrites; ligand-gated ionotropic
3
Q
M1
A
Nerves; Gq
4
Q
M2
A
Heart, nerves, smooth muscle; Gi
5
Q
M3
A
glands, smooth muscle, endothelium; Gq
6
Q
M4
A
CNS; Gi
7
Q
M5
A
CNS; Gq
8
Q
Cholinergic activation
A
Diarrhea
Urination
Miosis ("pin-prick" pupils)
Bronchoconstriction
Bradycardia
Emesis
Lacrimation
Salivation
Sweating
9
Q
Alpha1
A
Gq
10
Q
Alpha2
A
Gi
11
Q
Betas
A
Gs
12
Q
Cholinergic transportation
A
- ) Choline transported into presynaptic nerve terminal via sodium-dependent choline transporter
- ) In cytoplasm, ACh synthesized from choline and acetyl CoA by choline acetyltransferase
- ) Ach transported into storage vesicle by a vehicle-associated transporter
- )Ca channels open, vesicles fuse, exocytize Ach and cotransmitters
- ) Ach’s action terminated by metabolism of acetylcholinesterase
13
Q
Adrenergic transmission
A
- ) Tyrosine transported into noradrenergic nerve ending via sodium-dependent carrier
- ) Tyrosine converted to dopamine and transported into vesicle by vesicular monoamine transporter
- ) Same carrier transports NE and other amines into vesicle
- ) Dopamine converted to NE in vesicle by dopamine-beta-hydroxylase
- ) Ca channels open, vesicles fuse, NE, cotransmitters, and dopamine-beta-hydroxylase expelled
- ) NE diffuses out of the cleft, or is transported into cytoplasm of terminal by norepinephrine transporter
