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Year 2 Ocular Pharmacology > Autonomic pharmacology > Flashcards

Autonomic pharmacology Flashcards

1
Q

Where do the PS fibres in CN III originate from?

A

Edinger-Westphal nucleus

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2
Q

Which nerves innervate the iris sphincter and ciliary muscle?

A

Short ciliary nerves (from ciliary ganglion along inferior portion of ON III)

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3
Q

Where do the PS fibres in CN VII originate from?

A

Superior salivatory nucleus in brainstem

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4
Q

What is the name of the ganglion in CN VII?

A

Sphenopalatine/pterogopalatine ganglion

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5
Q

Where do the post ganglionic fibres of CN VII go?

A

Lacrimal gland

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6
Q

Which muscles are under PS innervation?

A

Ciliary muscle
Iris sphincter
Lacrimal gland

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7
Q

Is PS innervation cholinergic or adrenergic?

A

Cholinergic

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8
Q

PS innervation has … Preganglionic fibres and … Postganglionic fibres

A

Long
Short

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9
Q

Which muscles are under S innervation?

A

Iris dilator
Muller’s muscle
Ciliary muscle and epithelium

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10
Q

Is S innervation cholinergic or adrenergic?

A

Adrenergic

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11
Q

S innervation has … Preganglionic fibres and … Postganglionic fibres

A

Short
Long

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12
Q

Where does S innervation originate from?

A

Hypothalamus

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13
Q

What ganglion in the neck do S fibres synapse in?

A

Superior cervical ganglion

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14
Q

What do the S postganglionic fibres split into?

A

Long and short ciliary nerves

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15
Q

Which NS causes iris mydriasis?

A

Sympathetic

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16
Q

Which NS causes iris miosis?

A

Parasympathetic

17
Q

The ganglions for both S and PS nervous systems have …….. receptors.

A

Cholinergic

18
Q

The receptors at ganglion synapses in PS are ……

A

Nicotinic

19
Q

The receptors at neuro-muscular junctions in PS are ……

A

Muscarinic

20
Q

What enzymes are present in the PS synapse?

A

AChE
chAT
HACU

21
Q

What are the ways in which a drug can effect cholinergic synaptic transmission?

A

Parasympathomimetic
Anti muscarinic
Block acetylcholine synthesis
Prevent acetylcholine release
AChE inhibitor

22
Q

How does a parasympathomimetic work?

A

Mimics ACh, encouraging action

23
Q

How does an antimuscarinic work?

A

Blocks muscarinic receptors, stopping normal action from occuring

24
Q

How does blocking ACh synthesis/release work?

A

If no ACh produced/sent, signal not sent

25
Q

How does inhibiting AChE work?

A

Stops the breaking down of ACh, meaning choline is not reuptaken, so less ACh is re-released, stopping or slowing signal

Year 2 Ocular Pharmacology (20 decks)

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