Autonomic pharmacology Flashcards
Where do the PS fibres in CN III originate from?
Edinger-Westphal nucleus
Which nerves innervate the iris sphincter and ciliary muscle?
Short ciliary nerves (from ciliary ganglion along inferior portion of ON III)
Where do the PS fibres in CN VII originate from?
Superior salivatory nucleus in brainstem
What is the name of the ganglion in CN VII?
Sphenopalatine/pterogopalatine ganglion
Where do the post ganglionic fibres of CN VII go?
Lacrimal gland
Which muscles are under PS innervation?
Ciliary muscle
Iris sphincter
Lacrimal gland
Is PS innervation cholinergic or adrenergic?
Cholinergic
PS innervation has … Preganglionic fibres and … Postganglionic fibres
Long
Short
Which muscles are under S innervation?
Iris dilator
Muller’s muscle
Ciliary muscle and epithelium
Is S innervation cholinergic or adrenergic?
Adrenergic
S innervation has … Preganglionic fibres and … Postganglionic fibres
Short
Long
Where does S innervation originate from?
Hypothalamus
What ganglion in the neck do S fibres synapse in?
Superior cervical ganglion
What do the S postganglionic fibres split into?
Long and short ciliary nerves
Which NS causes iris mydriasis?
Sympathetic
Which NS causes iris miosis?
Parasympathetic
The ganglions for both S and PS nervous systems have …….. receptors.
Cholinergic
The receptors at ganglion synapses in PS are ……
Nicotinic
The receptors at neuro-muscular junctions in PS are ……
Muscarinic
What enzymes are present in the PS synapse?
AChE
chAT
HACU
What are the ways in which a drug can effect cholinergic synaptic transmission?
Parasympathomimetic
Anti muscarinic
Block acetylcholine synthesis
Prevent acetylcholine release
AChE inhibitor
How does a parasympathomimetic work?
Mimics ACh, encouraging action
How does an antimuscarinic work?
Blocks muscarinic receptors, stopping normal action from occuring
How does blocking ACh synthesis/release work?
If no ACh produced/sent, signal not sent
How does inhibiting AChE work?
Stops the breaking down of ACh, meaning choline is not reuptaken, so less ACh is re-released, stopping or slowing signal
