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pharmacology final ( 1st sem) > Autonomic NS- Cholinergic > Flashcards

Autonomic NS- Cholinergic Flashcards

1
Q

Muscarinic receptors- Which GPCR?

A 
M1- Gq
M2- Gi
M3- Gq
M4- Gi
M5- Gq
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2
Q

Adrenergic receptors- Which GPCR?

A 
a1- Gq
a2- Gi
B1- Gs
B2- Gs
B3- Gs
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3
Q

M1 location

A

Nerve endings

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4
Q

M2 location

A

Heart
SA
AV

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5
Q

M3 location

A

Smooth muscles

Glands

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6
Q

Describe the mechanism of far vision

A

Low Parasymp. tone (M3)
Relaxed ciliary muscles
Flat shape

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7
Q

Describe the mechanism of near vision

A

High Parasymp. tone (M3)
Contracted ciliary muscles
Spherical shape

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8
Q

Describe the mechanism of pupillary constriction

What is the name of the muscle?

A

High Parasymp. tone

Spincter pupillae

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9
Q

Describe the mechanism of pupillary dilation

What is the name of the muscle?

A

High symp. tone

Dilator pupillae

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10
Q

Pupillary dilation- which receptor plays a role?

A

a1

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11
Q

High aqueous humor production by what mechanism?

Agonist? Antagonist?

A

B2 agonists

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12
Q

Low aqueous humor production by what mechanism?

Agonist? Antagonist?

A

a2 agonists

B2 antagonists

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13
Q

Direct acting cholinomimetics and which receptors do they activate? (5)

A

Methacholine- M>N
Bethanechol- M
Pilocarpine- M

Carbachol- M, N

Vareniciline- N

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14
Q

I can treat Non obstructive ileus and urinary retention. Whcih drug am I?

A

Bethanechol

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15
Q

Carbachol can treat ____ through which mechanism?

A

Glaucoma

M-R agonist

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16
Q

Pilocarpine can treat

A

Glaucoma
Xerostomia
(CF sweat test)

17
Q

Which choilnomimetic drug can help with smoking cessation?

A

Varenciline

18
Q

Indirect acting cholinomimetics 3 groups and drugs of each group

A

Carbamates- Neostigmine, Pyridostigmine, Physostigmine, Rivastigmine, Galantamine, Donepezil
Organophosphates- Malathion, Parathion, Sarin
Alcohol- Edrophonium

19
Q

Main difference btw. Carbamates and organophosphates?

A

Carbamates are reversible and organophosphates are irreversible

20
Q

Which Carbamates enter the CNS?

A

Physostigmine
Rivastigmine
Galatamine
Donepezil

21
Q

Which Indirect acting cholinomimetics can help treat Alzheimer disease?

A

Rivastigmine
Galantamine
Donepezil

22
Q

Which drug can be used in the DD of Myasthenia Gravis?
What is the test?
What is the other possibility besides MG?

A

Edrophonium
Tensilon test
Cholinergic crisis (If there is no improved muscle tone)

23
Q

Whcih drug can be given in case of Atropine overdose?

A

Physostigmine

24
Q

Pyridostigmine main use

A

Treat MG

Topical in Glaucoma

25
Q

Neostigmine can be used in case of

A

MG
Non obstructive ileus
Urinary retention
Reversal of NM block

26
Q

AchE Inhibitors poisoning symptoms

A 
(DUMBBELS)
Diarrhea
Urination
Miosis
Bradycardia
Bronchoconstriction
Excitation
Lacrimation
Secretion
27
Q

Muscarinic antagonists (12)

A 
Atropine
Cyclopentolate
Scopolamine
Butyl-scopolamine
Procyclidine
Benztropine
Trihexyphenidyl
Solifenacil
Oxybutynin
Tolterodine
Ipratropium
Tiotropium
28
Q

Which Muscarinic antagonist have M3 selectivity?

A

Tiotropium

29
Q

Which Muscarinic antagonist drugs can help treat Parkinson?

A

Procyclidine
Benztropine
Trihexyphenidyl

30
Q

Which drug can regenerate cholinesterase?

A

Pralidoxime

31
Q

Which receptors have pre-synaptic inhibition activity?

A

a2

M2

32
Q

Which receptors have pre-synaptic stimulation activity?

A

M1
B2
AT-1
Prostaglandin

33
Q

Pre-synaptic inhibition drugs (3)

A

Hemicholinium
Vasemicol
Botulinium

34
Q

Pre-synaptic stimulation drugs (2)

A

4- aminopyridine

a- Latrotoxin

pharmacology final ( 1st sem) (15 decks)

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