Autonomic NS- Cholinergic Flashcards
Muscarinic receptors- Which GPCR?
M1- Gq M2- Gi M3- Gq M4- Gi M5- Gq
Adrenergic receptors- Which GPCR?
a1- Gq a2- Gi B1- Gs B2- Gs B3- Gs
M1 location
Nerve endings
M2 location
Heart
SA
AV
M3 location
Smooth muscles
Glands
Describe the mechanism of far vision
Low Parasymp. tone (M3)
Relaxed ciliary muscles
Flat shape
Describe the mechanism of near vision
High Parasymp. tone (M3)
Contracted ciliary muscles
Spherical shape
Describe the mechanism of pupillary constriction
What is the name of the muscle?
High Parasymp. tone
Spincter pupillae
Describe the mechanism of pupillary dilation
What is the name of the muscle?
High symp. tone
Dilator pupillae
Pupillary dilation- which receptor plays a role?
a1
High aqueous humor production by what mechanism?
Agonist? Antagonist?
B2 agonists
Low aqueous humor production by what mechanism?
Agonist? Antagonist?
a2 agonists
B2 antagonists
Direct acting cholinomimetics and which receptors do they activate? (5)
Methacholine- M>N
Bethanechol- M
Pilocarpine- M
Carbachol- M, N
Vareniciline- N
I can treat Non obstructive ileus and urinary retention. Whcih drug am I?
Bethanechol
Carbachol can treat ____ through which mechanism?
Glaucoma
M-R agonist
Pilocarpine can treat
Glaucoma
Xerostomia
(CF sweat test)
Which choilnomimetic drug can help with smoking cessation?
Varenciline
Indirect acting cholinomimetics 3 groups and drugs of each group
Carbamates- Neostigmine, Pyridostigmine, Physostigmine, Rivastigmine, Galantamine, Donepezil
Organophosphates- Malathion, Parathion, Sarin
Alcohol- Edrophonium
Main difference btw. Carbamates and organophosphates?
Carbamates are reversible and organophosphates are irreversible
Which Carbamates enter the CNS?
Physostigmine
Rivastigmine
Galatamine
Donepezil
Which Indirect acting cholinomimetics can help treat Alzheimer disease?
Rivastigmine
Galantamine
Donepezil
Which drug can be used in the DD of Myasthenia Gravis?
What is the test?
What is the other possibility besides MG?
Edrophonium
Tensilon test
Cholinergic crisis (If there is no improved muscle tone)
Whcih drug can be given in case of Atropine overdose?
Physostigmine
Pyridostigmine main use
Treat MG
Topical in Glaucoma
Neostigmine can be used in case of
MG
Non obstructive ileus
Urinary retention
Reversal of NM block
AchE Inhibitors poisoning symptoms
(DUMBBELS) Diarrhea Urination Miosis Bradycardia Bronchoconstriction Excitation Lacrimation Secretion
Muscarinic antagonists (12)
Atropine Cyclopentolate Scopolamine Butyl-scopolamine Procyclidine Benztropine Trihexyphenidyl Solifenacil Oxybutynin Tolterodine Ipratropium Tiotropium
Which Muscarinic antagonist have M3 selectivity?
Tiotropium
Which Muscarinic antagonist drugs can help treat Parkinson?
Procyclidine
Benztropine
Trihexyphenidyl
Which drug can regenerate cholinesterase?
Pralidoxime
Which receptors have pre-synaptic inhibition activity?
a2
M2
Which receptors have pre-synaptic stimulation activity?
M1
B2
AT-1
Prostaglandin
Pre-synaptic inhibition drugs (3)
Hemicholinium
Vasemicol
Botulinium
Pre-synaptic stimulation drugs (2)
4- aminopyridine
a- Latrotoxin
