Autonomic NS- Adrenergic Flashcards
Direct acting catecholamines
Epinephrine NE Dopamine Isoprenaline Dobutamine
Dobutamine Receptor preferance
B1 > B2»_space;> a1
doBButAmine
Epinephrine dose dependent effects
Low dose- B1, B2 agonist
High dose- a1 agonist
Epinephrine indications
Cardiac arrest Heart block Anaphylactic shock Hypotensive crisis Acute asthma attack
NE indications
Cardiac arrest
Heart block
Septic, Cardiogenic, Neurogenic shock
Hypotensive crisis
Dopamine dose dependent effects
Low dose- D1 stimulation (Increased renal perfusion)
Medium dose- B1 stimulation
High dose- Acts like Epi
Dopamine indication
Shock
With renal failure
Isoprenaline Receptor preferance
B1=B2
Iso isl like equally =
Dobutamine Receptor preferance
B1 > B2»_space;> a1
Dobutamine indication
Cardiogenic shock
Acute heart failure
Cardiac stimulation in cardiac stress test
a- agonists
Receptor preferance
Phenylephrine- a1 Oxymetazoline- local a1, systemic a2 Clonidine- a2, I2 Rimenidine- a2, I2 Methyldopa- a2 Brimonidine- a2 Tizanidine- a2
All -dine suffix is for a2-R
Long words are for a1-R
You cant measure BMR on CT
Clonidine indications
Antihypertensive
ADHD
Tourettes
Alcohol withdrawal synd.
Which a-agonist is indicated locally in case of Glaucoma?
Which R?
a2-R
Brimonidine
Which a-agonist is an orally taken muscle relaxant?
Which R?
a2-R
Tizanidine
B2- agonists
Albuterol Fenoterol Terbutaline Salmeterol Formeterol
AFT and FOR SALE-meterol
Albutarol is also called
Salbutamol
Short acting B2 agonists
Albuterol
Fenoterol
Terbutaline
Long acting B2 agonists
Salmeterol
Formoterol
Besides Asthma treatment, give another indication for Terbutaline?
Suppress premature labor
Indirect acting sympathomimetics can be 3 types
Release inducing
Reuptake inhibitors
MAO inhibitors
Indirect acting sympathomimetics
Release inducing
Amphetamine
Methylphenidate
Tyramine
Ephedrine
TEAM players!! they help release more
Indirect acting sympathomimetics
Reuptake inhibitors
+ MOA
Cocaine- NET+DAT inhibition
Atomoxetine- NE reuptake inhibition
Modafinil- NET+DAT inhibition
Indirect acting sympathomimetics
MAO inhibitors
+ MOA
Tanylcypromine- Non selective, irreversible
Moclobemide- MAO A, reversible
Selegiline- MAO B, reversible
Selegiline MOA+ indication
MAO B inhibition
Reversible
Parkinson
Tanylcypromine, Moclobemide indication
Antidepressant
Tanylcypromine is not longer used
Direct acting sympatholytics
a antagonists
Which R?
Phentolamine- Non selective Phenoxybenzamine- Non selective Prazosin- a1 Doxazosin- a1 Tamsulosin- a1 Urapidil- a1 antag, a2 agon, B antag, 5-HT agon Mitrazapine- a2
Direct acting sympatholytics
Only a1 antagonists
Prazosin
Doxazosin
Tamsulosin
Direct acting sympatholytics
Non selective a antagonists
Phentolamine
Phenoxybenzamine
Direct acting sympatholytics
a2 antagonist
Mitrazapine
Prazosin
Doxazosin
Tamsulosin
Indication
HTN
BPH -> relax muscle and allows urination
Which a1 antagonist is used in PTSD?
Prazosin
אתה צריך לקבל פרס אם אתה עוזר ל
PTSD
Non selective B-R antagonists
Propranolol
Timolol
Pindolol
Sotalol
Pls Tell People Sorry, we dont treat CHF
Selective B-1 antagonists
Bisoprolol Acebutolol Nebivolol Esmolol Metoprolol
BANE-M
Bane is the 1st bad guy in Batman
Combined a and B antag
Which R?
Cervedilol
Labetalol
ללללא קקקקריטי להם איזה רצפטור
Both B1, B2, a1 antagonists
Which B blockers have the highest lipid solubility?
Propranolol
Nebivilol
Bisoprolol
Indirect acting sympatholytics
Tyrosine hydroxilase inhibitor
Metyrosine
Tyrosine hydroxilase- tell me about it
Rate limiting step in catecholamine synthesis
Dopamine, NE, Epi..
Indirect acting sympatholytics
VMAT inhibitor
Reserpine
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