Autonomic Drugs -First Aid Reference

Question 1

name the adrenergic receptor

located in:
* vascular smooth muscle
* visceral smooth muscle

Answer 1

a1

Question 2

name the adrenergic receptor

effects:
* vasconstriction
* smooth muscle contraction

Answer 2

a1

Question 3

name the adrenergic receptor

location:
* presynaptic terminals
* salivary glands

Answer 3

a2

Question 4

name the adrenergic receptor

effect:
inhibition of neurotransmitter release

Answer 4

a2

Question 5

name the adrenergic receptor

location:
* heart
* kidney

Answer 5

b1

Question 6

name the adrenergic receptor

• increase heart rate
• increase renin secretion

effects

Answer 6

b1

Question 7

name the adrenergic receptor

location:
* bronchioles
* cardiac muscle
* liver
* visceral smooth muscle

Answer 7

b2

Question 8

name the adrenergic receptor

effect:
* bronchodilation
* increase HR and contractility
* inhibition of insulin secretion
* vasodilation

Answer 8

b2

Question 9

name the adrenergic receptor

location:
adipose

Answer 9

b3

Question 10

name the adrenergic receptor

effect:
lipolysis

Answer 10

b3

Question 11

name the adrenergic receptor

effect:
decrease heart rate and contractility

Answer 11

m2

Question 12

name the adrenergic receptor

effect:
increase exocrine gland secretions
increase peristalsis
increase bladder contraction
bronchoconstriction
pupillary constriction

Answer 12

m3

Question 13

indirect cholinergic agonists: carbamates

2

Answer 13

• psysostigmine
• neostigmine

Question 14

increases ACh
used for:
* reversal of neuromuscular junction blockade
* post operative urinary retention

Answer 14

neostigmine

Question 15

• increases ACh
• cross blood-brain barrier
• antidote for anticholinergic toxicity

Answer 15

physostigmine

Question 16

• simple alcohol ester
• very short half-life
• increases ACh
• historically used to dx MG

Answer 16

edrophonium

Question 17

• muscarinic antagonist
• used in eye
• produces mydriasis and cycloplegia

Answer 17

atropine

Question 18

• muscarinic antagonist
• quaternary amine
• used for COPD, asthma

Answer 18

ipratropium

Question 19

• muscarinic antagonist
• affects CNS
• used for motion sickness
• tertiary amine

Answer 19

scopalamine

Question 20

direct sympathomimetics
increase HR
used for asthma/COPD

2

Answer 20

albuterol
salmeterol

Question 21

selectivity: albuterol and salmeterol

Answer 21

b2>b1

Question 22

• direct sympathomimetic
• decreases BP
• increase HR
• increase CO
• inotrope

Answer 22

dobutamine

Question 23

selectivity: dobutamine

Answer 23

b1>b2, a

Question 24

• direct sympathomimetic
• increases BP at high doses
• increase heart rate
• increase CO
• anaphylaxis, shock asthma, glaucoma

Answer 24

epinephrine

Question 25

selectivity: epinephrine

Answer 25

b>a

Question 26

epinephrine: [...] effects predominate at high doses

Answer 26

alpha

Question 27

stronger effect at b2 than noepinephrine

Answer 27

epinephrine

Question 28

* direct sympathomimetic * decrease BP (vasodilation) * increase HR * increase CO * nonselective

Answer 28

isoproterenol

Question 29

selectivity: isoproterenol

Answer 29

b1=b2

Question 30

* direct sympathomimetic * increase BP * hypotension * septic shock

Answer 30

norepinephrine

Question 31

selectivity: norepinephrine

Answer 31

a1>a2>b1

Question 32

* direct sympathomimetic * increase BP (vasocontriction) * decrease HR * decrease CO * hypotension * decongestant * mydriasis

Answer 32

phenylephrine

Question 33

selectivity: phenylephrine

Answer 33

a1>a2

Question 34

* indirect sympathomimetic * reuptake inhibitor * releases stored catecholamines

Answer 34

amphetamine

Question 35

* indirect sympathomimetic * reuptake inhibitor * vasocontriction * local anesthesia * mydriasis

Answer 35

cocaine

Question 36

* indirect sympathomimetic * releases stored catecholamines * nasal decongestant * hypotension

Answer 36

ephedrine

Question 37

* caution when giving with b-blockers * unopposed a1 activation will cause massive increase in BP

Answer 37

cocaine

Question 38

norepinephrine + isoproterenol

Answer 38

NE is a1 agonist (increased MAP + bradycardia) isoproterenol is b2 agonist (vasodilation) **Net:** * mean decrease in MAP * increased HR

Question 39

* a2 agonist * hypertension in pregnancy

Answer 39

methyldopa

Question 40

* nonselective alpha blocker * irreversible * used preop to prevent chatecholamine crisis * can cause orthostatic hypotension, relex tachy

Answer 40

phenoxybenzamine

Question 41

* nonselective alpha blocker * reversible * can cause orthostatic hypotension, relex tachy

Answer 41

phentolamine

Question 42

a1 selective alpha blockers

Answer 42

prazosin terazosin doxazosin

Question 43

adverse effects of a1 selective alpha blockers

Answer 43

orthostatic hypotension dizziness headache

Question 44

b1 selective antagonists

Answer 44

atenolol metoprolol

Question 45

nonselective antagonist beta blockers | B1=B2

Answer 45

nadolol timolol propranolol

Question 46

nonselective a and b antagonist

Answer 46

labetalol