Autoimmunity, Hypersensitivity,Immunodeficiency, & AIDS Flashcards
how is Type I hypersensitivity mediated?
IgE mediated degranulation of mast cells that causes histamine release
what can cause Type I hypersensitivity reaction?
drugs
bee stings
asthma
what mediates Type II hypersensitivity reaction?
antibody mediated or compliment mediated cell lysis
what causes type II hypersensitivity reactions?
transfusion reactions
myasthenia gravis
what mediates type III hypersensitivity
mediated by antigen-antibody complex deposition disease
what can cause type III hypersensitivity reaction?
post-strep glomerulonephritis
lupus
how is type IV hypersensitivity mediated?
delayed T cell mediated
what can cause type IV hypersensitivity
contact dermatitis
Tb skin test
primary immunodeficiency
congenital
aids
secondary immunodeficiency
age
chronic disease
stress
malnutrition
steroids
clinical manifestation of hematologic malignancy
fever, weight loss, night sweats, fatigue, headache
bone pain
anemia or polycythemia
leukopenia or leukocytosis
hypercalcemia
chronic hematologic malignancy
Mature cells
Slow onset
Usually Adults
acute hematologic malignancy
Blasts (immature cells)
Fast onset
All ages
diagnosis of AIDS
CD4 count <200
defining clinical conditions
- PCP pneumonia
- oral or systemic candidiasis
- Tb
- systemic fungal infections
early signs and symptoms - Anti-retroviral syndrome
Fever
Pharyngitis
Weight loss (wasting and malnutrition)
Diarrhea
Fatigue
Joint pains
Nausea/Vomiting
