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ESA 4 missing > Autoimmune Not On Brainscape > Flashcards

Autoimmune Not On Brainscape Flashcards

1
Q

How does autoimmunity occur

A

Breakdown of central tolerance
- failure to delete auto reactive t or B cells

Breakdown of peripheral tolerance

  • regulatory T cell deficits
  • impaired immunomodulation
  • altered self antigens

Activation of auto reactive B cells

  • T cell independent activation
  • carrier effect
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2
Q

Hashimotis self antigen

A

Thyroid peroxidase and thyroglobulin

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3
Q

T1DM self antigen

A

Proteins in pancreatic island cell

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4
Q

Multiple sclerosis self antigen

A

Myelin sheath

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5
Q

Goodpastures self antigen

A

GMB

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6
Q

Addisons self antigen

A

Steroid 21 hydroxylase in adrenal cortex

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7
Q

Graves self antigen

A

TSH receptor

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8
Q

MG self antigen

A

ACH receptor

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9
Q

Pernicious anaemia self antigen

A

Intrinsic factor and parietal cells

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10
Q

Autoimmune haemolytic anaemia self antigen

A

RBC antigens

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11
Q

RA self antigen

A

Rheumatoid factor- Fc portion of IgG

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12
Q

SLE self antigen

A

Ds DNA plus histones

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13
Q

Sjorgens syndrome self antigen

A

Nuclear antigens- Ro and La

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14
Q

Autoimmune diseases that are type IV hypersensitivity

A
  • hashimotos
  • T1DM
  • multiple sclerosis
  • addisons
  • RA
  • sjorgens syndrome
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15
Q

Autoimmune diseases that are type II hypersensitivity

A 
Good pastures
Graves
MG
Pernicious anaemia 
Autoimmune haemolytic anemia
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16
Q

Autoimmune diseases that are type III hypersensitivity

17
Q

What does sjorgens syndrome cause

A

Dry eyes, mouth and arthritis

18
Q

Antibody in lambert Eaton myasthenia syndrome

A

Anti voltage gated Ca2+ channel

19
Q

What is the significance of primary autoantibodies

A
  • drive disease

- if removed via plasmapheresis then symptoms are alleviated

20
Q

Which diseases tested for by immune fluorescence

A 
T1DM
goodpastures 
Addisons
Pernicious anaemia 
SLE
21
Q 
How test for 
Hashimotos 
MG
HDN/autoimmune haemolytic anaemia 
SLE
RA
A 
Hashimotos - infiltration T cells 
MG- radioimmunoassay 
HDN/autoimmune haemolytic anaemia  - coombs
SLE- radioimmunoassay
RA- agglutination
22
Q

What bacteria and antigen can cause rheumatic fever

A
  • steptococcus pyogenes m protein

- antigen in cardiac muscle

23
Q

What bacteria and antigen can cause guillian barre

A
  • campylobacter jejuni glycoproteins

- myelin associated gangliosides

24
Q

What bacteria and antigen can cause T1DM

A

Coxasakieviruse B4 nuclear protein

Pancreatic island cell

25
Q

What bacteria and antigen can cause haemolytic anemia

A

Chlamydia trachomatis

Red blood cells

26
Q

What can d-penicillamine induce

A

MG
Pemphigus
SLE
Glomerulonephritis

27
Q

What drug

MG
Pemphigus
SLE
Glomerulonephritis

A

D- penicillamine

28
Q

What can methyldopa induce

A

Haemolytic anaemia

29
Q

What drug induce Haemolytic anaemia

A

Methyldopa

30
Q

What drug induce SLE

A

Hydralazine
Procainamide
Isoniazid
Minocycline

31
Q

Hydralazine
Procainamide
Isoniazid
Minocycline

What disease???

32
Q

Treatment hashimotos, T1DM, addisons, pernicious anaemia

A

Replacement therapy

33
Q

Treatment multiple sclerosis

A

Anti inflammatory drugs

Monoclonal antibodies

34
Q

Treatment goodpastures

A

Plasmapharesis, cytotoxic drugs, renal dialysis

35
Q

Treatment graves

A

Anti thyroid drugs, plasma paresis, surgery

36
Q

Treatment MG

A

Anticholinesterase, immuno suppressive drugs, plasmapharesis

37
Q

Treatment autoimmune haemolytic anaemia

A

Anti inflammatory drugs , splenectomy

38
Q

Treatment RA

A

Immune suppressive drugs, splenectomy

39
Q

Treatment SLE

A

Immunosuppressive drugs, monoclonal antibodies

ESA 4 missing (5 decks)

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