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Year 5 > Autoantibodies and their associated diseases > Flashcards

Autoantibodies and their associated diseases Flashcards

1
Q

Rheumatoid factor

A

RA 85% spec and sen

5% normal population and incidence increases with age

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2
Q

Anti- CCP (cyclic citrullinated protein)

A

RA 95% specific, 65% sen

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3
Q

ANA

A

CTD
97% SLE
Does not change with disease activity
5% normal population

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4
Q

dsDNA

A

SLE - increases with disease activity

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5
Q

Anti - Ro and La

A

Sjorgrens disease

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6
Q

Anti-Sm

A

SLE (not all pts)

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7
Q

Anti- histone

A

Drug induced lupus

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8
Q

Ansi-Scl-70

A

Diffuse systemic sclerosis

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9
Q

Anti-centromere

A

Limited systemic sclerosis - CREST

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10
Q

Anti-Jo-1

A

Interstitial lung disease in polymyositis

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11
Q

Anti-cardiolipin antibodies

A

Anti phospholipid syndrome (checked alongside lupus anti-coagulant)

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12
Q

ANCA anti neutrophil cytoplasmic antibodies

A

Vasculitis (not specific)
c-ANCA Wegners
p-ANCA polyarteritis

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13
Q

anti-GBM

A

Goodpastures

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14
Q

cANCA

A

granulomatosis with polyangiitis (Wegener’s granulomatosis)

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15
Q

pANCA

A
  • associated with immune crescentic glomerulonephritis (positive in c. 80% of patients)
  • microscopic polyangiitis, positive in 50-75%
  • Churg-Strauss syndrome, positive in 60%
  • primary sclerosing cholangitis, positive in 60-80%
  • granulomatosis with polyangiitis
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16
Q

random causes positive ANCA

A

usually pANCA
•inflammatory bowel disease (UC > Crohn’s)
•connective tissue disorders: RA, SLE, Sjogren’s
•autoimmune hepatitis

17
Q

Antimitorchondrial

A

PBC

18
Q

Anti sm muscle

A

AI Hepatitis

19
Q

Gastric parietal Ab

A

Pernicious anaemia

20
Q

Anti TTg

A

Coeliac

21
Q

Anti TPO

A

Hashimotos Thyroiditis

22
Q

Anti ACh receptor

A

Myasthenia Gravis

23
Q

Anti Ca2+ channel

A

Lambert eaton

24
Q

Antibody to the TSH receptor

A

Graves disease - causes chronic stimulation

Year 5 (9 decks)

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