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COMLEX 1 > Autoantibodies > Flashcards

Autoantibodies Flashcards

1
Q

Anti-ACh receptor

A

myasthenia gravis

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2
Q

anti-presynaptic voltage-gated calcium channel

A

Lambert-Eaton myasthenic syndrome

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3
Q

anti-beta2 glycoprotein

A

antiphospholipid syndrome

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4
Q

antinuclear

A

nonspecific screening antibody, often assoc w/ SLE

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5
Q

anticardiolipin, lupus anticoagulant

A

SLE, antiphoshpolipid syndrome

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6
Q

anti-dsDNA, anti-Smith

A

SLE

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7
Q

anti-histone

A

drug-induced lupus

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8
Q

anti-U1 RNP (ribonucleoprotein)

A

mixed connective tissue disease

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9
Q

rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific)

A

rheumatoid arthritis

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10
Q

anti-Ro/SSA, anti-La/SSB

A

Sjogren syndrome

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11
Q

anticentromere

A

limited scleroderma (CREST)

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12
Q

anti-Scl-70 (anti-DNA-topoisomerase-I)

A

scleroderma (diffuse)

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13
Q

antisynthetase (e.g. anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2)

A

polymyositis, dermatomyositis

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14
Q

antimitochondrial primary biliary cirrhosis

A

primary biliary cholangitis

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15
Q

anti-smooth muscle

A

autoimmune hepatitis type 1

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16
Q

MPO-ANCA/p-ANCA

A

microscopic polyangitis, eosinophilic granulomatosis with polyangitis (Churg-Strauss syndrome), ulcerative colitis

17
Q

PR3-ANCA/c-ANCA

A

granulomatosis with polyangiitis (Wegener)

18
Q

anti-phospholipase A2 receptor

A

primary membranous nephropathy

19
Q

anti-hemidesmosome

A

bullous pemphigoid

20
Q

anti-desmoglein (anti-desmosome)

A

pemphigus vulgaris

21
Q

antimicrosomal, antithyroglobulin, antithyroid peroxidase

A

Hashimoto thyroiditis

22
Q

anti-TSH receptor

A

Graves disease

23
Q

anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deaminated gliadin peptide

A

Celiac disease

24
Q

anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

A

Type 1 diabetes mellitus

25
Q

anti parietal cell, anti-intrinsic factor

A

pernicious anemia

26
Q

anti-glomerular basement membrane

A

Goodpasture syndrome

COMLEX 1 (14 decks)

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