Autoantibodies

Question 1

anti-IgG antibodies

Answer 1

rheumatoid arthritis

IgM antibody specific to IgG Fc region

Question 2

anti-citrullinated protien antibodies (ACPA)/anti-CCP

Answer 2

rheumatoid arthritis

Question 3

anti-centromere antibodies

Answer 3

CREST syndrome (limited scleroderma)

Question 4

anti-Scl-70 (anti-DNA topoisomerase I)

Answer 4

Scleroderma (diffuse)

Question 5

anti-histone

Answer 5

drug-induced lupus

Question 6

antinuclear antibodies (ANA)

Answer 6

SLE, nonspecific

Question 7

anti-Smith (anti-dsDNA)

Answer 7

SLE

Question 8

anti-Jo-1, anti-SRP, anti-Mi-2

Answer 8

polymyositis

dermatomyositis

Question 9

anti-SSA (anti-Ro), anti-SSB (anti-La)

Answer 9

Sjogren syndrome

Question 10

anti-U1-RNP

Answer 10

mixed connective tissue disease

Question 11

anti-desmoglein

Answer 11

pemphigus vulgaris

Question 12

anti-acetylcholine receptor

Answer 12

myasthenia gravis

Question 13

IgA anti-endomysial (anti-tissue transglutaminase)

Answer 13

Celiac disease

Question 14

anti-gliadin

Answer 14

Celiac disease

Question 15

anti-mitochondrial

Answer 15

primary biliary cirrhosis

Question 16

anti-smooth muscle

Answer 16

autoimmune hepatitis

Question 17

anti-glutamate decarboxylase

Answer 17

type I DM

Question 18

anti-thyrotropin receptor

Answer 18

Graves disease

Question 19

anti-thyroid peroxidase (anti-TPO)

Answer 19

Hashimoto thyroiditis

Question 20

anti-thyroglobulin

Answer 20

Hashimoto thyroiditis, Graves disease

Question 21

anti-basement membrane

Answer 21

Goodpasture syndrome

Question 22

c-ANCA (PR3-ANCA)

Answer 22

Granulomatosis with polyangiitis (Wegener)

Question 23

p-ANCA (MPO-ANCA)

Answer 23

pauci-immune crescentic glomerulonephritis
Churg-Strauss syndrome
Microscopic polyangiitis

Question 24

anti-hemidesmosome

Answer 24

bullous pemphigoid