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Jess > Auto-antibodies > Flashcards

Auto-antibodies Flashcards

1
Q

Antiphospholipid syndrome

A

Anti-cardiolipin and beta2 glycoprotein

Lupus anticoagulant

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2
Q

Autoimmune hepatitis

A

Anti-smooth muscle antibody
Anti-LKM-1
Anti-soluble liver antigen (anti-SLA)

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3
Q

Autoimmune haemolytic anaemia

A

Anti-Rhesus

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4
Q

Autoimmune thrombocytopenic purpura (ITP)

A

Anti-glycoprotein IIb-IIIa

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5
Q

Churg-Strauss Syndrome (eGPA)

A

p-ANCA

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6
Q

Coeliac disease

A

Anti-TTG

Anti-endomysial

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7
Q

Congenital heart block in infants of mothers with SLE

A

Anti-Ro

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8
Q

Dermatitis herpetiformis

A

Anti-endomysial antibody (IgA)

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9
Q

Dermatomyositis

A

Anti-Jo-1 (t-RNA synthetase)

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10
Q

Diffuse cutaneous scleroderma

A

Anti-Scl70 (anti-topoisomerase)
RNA Pol I, II, III
Fibrillarin (nucleolar pattern)

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11
Q

Goodpasture’s syndrome

A

Anti-GBM (against type IV collagen; linear pattern)

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12
Q

Graves disease

A

Anti-TSH (stimulatory)

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13
Q

Hashimoto’s thyroiditis

A

Anti-TPO

Anti-thyroglobulin

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14
Q

Limited cutaneous scleroderma (CREST)

A

Anti-centromere antibody

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15
Q

Microscopic polyangiitis

A

p-ANCA

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16
Q

Mixed connective tissue disease

A

Anti-U1RNP (speckled pattern)

17
Q

Myasthenia gravis

A

Anti-acetylcholine receptor

18
Q

Pernicious anaemia

A

Anti-intrinsic factor

Anti-gastric parietal cells

19
Q

Polymyositis

A

Anti-Jo-1 (t-RNA synthetase)

20
Q

Primary biliary cirrhosis

A

Anti-mitochondrial antibody

21
Q

Rheumatoid arthritis

A

Anti-CCP

Rheumatoid factor

22
Q

Sjogren’s syndrome

A 
Anti-Ro, Anti-La (speckled pattern)
Rheumatoid factor (70%)
23
Q

SLE

A

Anti-dsDNA

Plus anti-histones, Ro, La, Sm and U1RNP (speckled)

24
Q

T1DM

A

Anti-GAD

25
Q

Wegener’s granulomatosis (GPA)

A

c-ANCA

26
Q

Polyarteritis nodosa

A

p-ANCA (ass’d with Hep B)

27
Q

Primary sclerosing cholangitis

A

p-ANCA

Jess (8 decks)

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