Autacoids Flashcards
What are autocoids?
What are the 4 main classifications of autacoids?
What are the main function of autocoids?
Where was serotonin discovered?
What the functi9ons of seratonin in the CNS vs periphery?
How is serotonin biosynthesis and degraded?
Where is serotonin mainly produced?
What is the role of platelets in working with seratonin?
How many serotonin receptor subtypes are there?
Which serotonin receptor mediates platelet aggregation?
How is 5-HT3 receptor related to vomiting?
How do chemo drugs reduce vomiting?
Which serotonin receptor is involved in peristalsis?
Where are EC cells?
When does peristalsis occur?
What is IPAN?
What are the 2 types of GI motility?
What receptor subtype would you target for IBS?
What % of the population has IBS?
What antidepressant drug class is used to treat IBS?
Which 5-HT receptors are present in the CNS?
What does serotonin regulate in the CNS?
What are SSRIs used for?
Discuss the discovery of Histamine?
How is histamine synthesised and metabolised?
How is histamine distributed and stored?
What are the two ways of histamine release?
How many histamine receptor subtypes have been identified?
How does mast cell degranulation occur?
What is the triple response of lewis?
How does histamine trigger a respone?
What are the most common symptoms of allergic reactions?
What is the mechanism of action of antihistamine?
What are 5 clinical uses of H1 antihistamines?
Discuss the discovery of NO.
What is NO?
How is NO biosynthesised?
What are the isoenzymes of NOS (nitric oxide synthase)?
Draw a diagram showing how NO induces blood vessel dilation.
What 2 drug classes have bee developed to target NO production/ action?
How does iNOS impact inflammation?
What is nNOS and what does it do?
What does nNOS do in the enteric nervous system?
What does NO do in peristalsis?
What is peptic ulcer disease (PUD)?
What are the major functions of the stomach?
How is gastric acid secreted and how does it stimulate the digestion of food?
What are 3 endogenous stimulants of gastric acid?
How is acid secretion inhibited?
What are the 3 protective layers in the stomach’s mucosal defence?
What are some causes of PUD?
What is H. pylori?
Discuss the discovery of H. pylori.
Discuss the prevalence of H. pylori.
Where does H. pylori live in the stomach?
How does H- pylori protect itself from gastric acid?
How does H. pylori cause stomach problems?
What are the signs and symptoms of PUD?
How is H. pylori spread?
How is PUD treated?
How can stomach pH be increased?
Why are muscarinic antagonists not recommended to treat PUD?
How do H2-receptor antagonists work?
What is Nizatidine?
What are Antacids?
What makes Esomeprazole a useful PPI?
When would IV PPI be indicated rather than oral?
What is the mechanism of PPIs?
What treatment is used to eradicate H. Pylori infections?
What do amoxicillin antibiotics do?
What do clarithromycin antibiotics do?
What do esomeprazole or omeprazole antibiotics do?
What is a migrane?
What are the 3 types of migranes? What is their prevalence?
What a severe risk factor of women with migranes?
How is serotonin involved in migraines?
What are 2 serotonin receptors involved in migraines?
Draw a diagram showing how peripheral 5-HT can lead to pain and Aura in the CNS.
What are 3 kinds of 5-HT related drugs that target migraines?
What are Triptans?
What is the clinical use of 5-HT1 agonists?
What is the clinical use of 5-HT2 antagonists?
What is the clinical use of 5-HT3 antagonists?
What is the clinical use of 5-HT4 agonists?
What is the clinical use of SSRIs?
