Anti-inflammatory Flashcards by Gabriella Munoz

List some inflammaotory mechanisms

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Discuss eicosanoid biosynthesis

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Discuss the types and actions of prostanoids

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Discuss the actions of leukotrienes

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What are some anti-imflammatory agents

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Why is paracetamol classed differently?

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What are the 3 major types of effect if NSAIDs?

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What are the chemical classes of NSAIDs?

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Contrast and compare COX-1 and COX-2

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How can inhibition of cyclco-oxygenase occur?

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What are the anti-inflammatory actions of NSAIDs?

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Discuss the antipyretic actions of NSAIDs

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What are the analgesic actions of NSAIDs?

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Summarise the mechanism of action of NSAIDs.
How is it metabolised?
What actions do the resulting products have?
What effect does this have on the patient?

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What are the side effects of NSAIDs in the GI, Renal and other systems?

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Why is the use of NSAIDs dangerous for asthamtics?

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How were selective COX-2 drugs made, and why?

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Discuss Aspirin. Why is it not used as an anti-inflam?

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When and when would you not recommend a CSI?

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What are 4 examples of CSIs? Which is discontinued?

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Compare GI bleeds in Rofecoxib and Naproxen?

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Why do we see cardiovascular side effects in CSIs?

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Discuss paracetamol. What pathway does it target? Why is is preferential? What can occur during an overdose?

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Discuss topical opthalamic NSAIDs.

What are corticosteroids?

What is the HPA Axis?

What are the anti-inflammatory effects of corticosteroids?

What are the hyperglycemic effects of corticosteroids?

What are the altered lipid distribution effects of corticosteroids?

What are the blood cell effects of corticosteroids?

What inflammatory conditions are indications for GCs?

What are systemic side effects of GCs?

How do GCs produce their inflammatory actions?

What are the 2 sites of action of GCs?

How are GCs immunosuppressant?

What is the mechanism of action of GCs?

What are antihistamines?

What is asthma?

What are 3 types of asthma?

What are 5 stimuli that trigger asthma?

What are the 2 phases of asthma?

how is asthma managed?

what are 3 kinds of treatments for asthma?

Why are asthma treatments best inhaled?

Which receptors are present in the airways of smooth muscle and what do they do?

What are beta-agonists used for in asthma?

what are 4 side effects/ complications of b-agonists?

How do m-antagonists treat asthma or OPD?

How do GCs effects eicosanoid biosynthesis?

What is the action of GCs in asthma?

What are side effects of inhales GCs?

What combination therapy is used for asthma?

Discuss the use of leukotriene receptor antagonists in asthma?

Why is aspirin not recommended for asthmatics?

What is the mechanisms of action of leukotriene synthesis inhibitors?

What are sodium cromoglycate and nedocromil sodium and when are they most effective?

What is status asthmaticus? How is it treated?

What are the 2 major types of arthritis?