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Pharm2011 > Anti-inflammatory > Flashcards

Anti-inflammatory Flashcards

1
Q

List some inflammaotory mechanisms

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2
Q

Discuss eicosanoid biosynthesis

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3
Q

Discuss the types and actions of prostanoids

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4
Q

Discuss the actions of leukotrienes

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5
Q

What are some anti-imflammatory agents

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6
Q

Why is paracetamol classed differently?

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7
Q

What are the 3 major types of effect if NSAIDs?

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8
Q

What are the chemical classes of NSAIDs?

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9
Q

Contrast and compare COX-1 and COX-2

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10
Q

How can inhibition of cyclco-oxygenase occur?

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11
Q

What are the anti-inflammatory actions of NSAIDs?

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12
Q

Discuss the antipyretic actions of NSAIDs

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13
Q

What are the analgesic actions of NSAIDs?

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14
Q

Summarise the mechanism of action of NSAIDs.
How is it metabolised?
What actions do the resulting products have?
What effect does this have on the patient?

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15
Q

What are the side effects of NSAIDs in the GI, Renal and other systems?

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16
Q

Why is the use of NSAIDs dangerous for asthamtics?

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17
Q

How were selective COX-2 drugs made, and why?

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18
Q

Discuss Aspirin. Why is it not used as an anti-inflam?

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19
Q

When and when would you not recommend a CSI?

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20
Q

What are 4 examples of CSIs? Which is discontinued?

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21
Q

Compare GI bleeds in Rofecoxib and Naproxen?

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22
Q

Why do we see cardiovascular side effects in CSIs?

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23
Q

Discuss paracetamol. What pathway does it target? Why is is preferential? What can occur during an overdose?

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24
Q

Discuss topical opthalamic NSAIDs.

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25
Q

What are corticosteroids?

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26
Q

What is the HPA Axis?

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27
Q

What are the anti-inflammatory effects of corticosteroids?

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28
Q

What are the hyperglycemic effects of corticosteroids?

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29
Q

What are the altered lipid distribution effects of corticosteroids?

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30
Q

What are the blood cell effects of corticosteroids?

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31
Q

What inflammatory conditions are indications for GCs?

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32
Q

What are systemic side effects of GCs?

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33
Q

How do GCs produce their inflammatory actions?

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34
Q

What are the 2 sites of action of GCs?

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35
Q

How are GCs immunosuppressant?

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36
Q

What is the mechanism of action of GCs?

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37
Q

What are antihistamines?

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38
Q

What is asthma?

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39
Q

What are 3 types of asthma?

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40
Q

What are 5 stimuli that trigger asthma?

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41
Q

What are the 2 phases of asthma?

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42
Q

how is asthma managed?

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43
Q

what are 3 kinds of treatments for asthma?

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44
Q

Why are asthma treatments best inhaled?

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45
Q

Which receptors are present in the airways of smooth muscle and what do they do?

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46
Q

What are beta-agonists used for in asthma?

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47
Q

what are 4 side effects/ complications of b-agonists?

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48
Q

How do m-antagonists treat asthma or OPD?

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49
Q

How do GCs effects eicosanoid biosynthesis?

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50
Q

What is the action of GCs in asthma?

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51
Q

What are side effects of inhales GCs?

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52
Q

What combination therapy is used for asthma?

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53
Q

Discuss the use of leukotriene receptor antagonists in asthma?

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54
Q

Why is aspirin not recommended for asthmatics?

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55
Q

What is the mechanisms of action of leukotriene synthesis inhibitors?

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56
Q

What are sodium cromoglycate and nedocromil sodium and when are they most effective?

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57
Q

What is status asthmaticus? How is it treated?

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58
Q

What are the 2 major types of arthritis?

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Pharm2011 (7 decks)

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