atherosclerosis Flashcards
What are the antiinflammatory cytokines?
IL10 and TGF beta
TH2
from Treg cells
what would happen if we blocked IL10 and TGFbeta?
plaque formation would increase
what are the inflammatory cytokines we need to consider?
IL 1, interferon gamma, TNF alpha
What cells accumulate in artherosclerotic plaque?
macrophages and T lymphocytes
What brings in the T lymphocytes?
the foam cells after releasing cytokines
foam cells are macrophages that have engulfed lipids
What is the innate main host defense?
T cells signaled by VCAM and ICAM
What two cytokines stimulate Th1?
IL12 and IL18
Does Th1 inc or dec plaque formation?
inc plaque formation
In what ways could we target plaque formation?
vaccine to ox LDL like B lymphocytes
anti IL1
alter Th1 and Th2 balance
Lab evaluations to look at plaque formation
c reactive proteins inflammatory cytokines (IL6)
What precipitates plaque formation?
an inflammatory response that damages endothelium of artery
usually triggered by oxidation of lipoproteins
What effect does Th2 have on plaque formation?
decrease plaque formation
pathogenesis of plaque formation
inflammation of vessel -> adhesion molecules & LDL ->leukocytes invade -> macrophages -> foam cells -> cytokines and T cells -> smooth muscle cell proliferation -> elastin and collagen degredation ->weakening of fibrous cap -> rupture
