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Immunology > Asthma And Copd > Flashcards

Asthma And Copd Flashcards

0
Q

What does Th2 do in asthma?

A

Helps B cells switch to IgE isotope

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1
Q

What does IL 4 do in asthma?

A

Promote Th2

Enhance IgE switch

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2
Q

What happens on a microscopic level for Reexposure to an antigen in asthma?

A

Dear halting of mast cells from the binding of IgE

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3
Q

What is atopy?

A

Exaggerated tendency to form IgE to allergens

Increased eosinophils

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4
Q

What does IgE beta chain do for asthma?

A

Increases affinity for FCe receptor on mast cells

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5
Q

What does the TIM gene family do in asthma?

A

Regulates Th1 Th2 balance

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6
Q

What is the hygiene hypothesis?

A

Since newborns more apt to form Th2, they need exposure to Th1 forming things like viral infections to generate a balance. This cannot be accomplished in a super hygienic environment and will cause asthma or other atopic events like eczema and allergic rhinitis

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7
Q

What cytokines cause B cells to switch to IgE?

A

Low IL 12
High IL 4
IL 13

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8
Q

What type of response is allergic asthma?

A

Type I precipitated by a previous Type IV response

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9
Q

For asthma, what does a type IV response create?

A

Switch from IgG to IgE

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10
Q

For asthma, what does a type I response create?

A

Mast cell de granulation

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11
Q

Preformed mast cell mediators?

A

Histamines
Proteoglycans
Tryptase
Chymase

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12
Q

What type of reaction do typeI hypersensitivity mediators induce?

A

Vasodilation
Brochoconstriction
Inflammation
Mucus secretion

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14
Q

Full copd is due to what three things?

A

Environmental stimuli
Genetic susceptibility
Failure of immunoregulatory mechs

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15
Q

What causes the inflammation in COPD?

A

ROS due to neutrophils and macrophages

CD8 T cells

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16
Q

What is the danger hypothesis?

A

cells being damaged by exposures release danger signals that bind to toll like receptors
this leads to inflammation
act of neutrophils and macrophages which release proteolytic enzymes

17
Q

What T cell would down regulate the pathophys of COPD?

A

Treg

18
Q

What is the purpose of Tfh?

A

helps B cells make IgG and IgA

part of the possible autoimmunity aspect of the disease

19
Q

Overview of asthma?

A 
reversible inflammation
extrinsic inciting antigen
CD4, Th2
IL4
Effectors-B cells, IgE, mast cells
20
Q

Overview of COPD?

A 
irreversible inflammation
intrinsic inciting factor
CD4, Th1
IL 12
Effectors- CD8, macrophages/neutrophils
21
Q

What is the purpose of Th1?

A

incite cell mediated immunity and inflammatory cytokines

22
Q

What is the purpose of Th2?

A

evoke strong antibody response

23
Q

What 2 reactions are associated w/ asthma?

A

first a type Iv reaction to create IgE

then Type I reaction everytime an antigen is detected

Immunology (4 decks)

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