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Y1Systems > Asthma Clinical Features, Adults and Children > Flashcards

Asthma Clinical Features, Adults and Children Flashcards

1
Q

What is asthma characterised by?

A

Increased responsiveness of trachea and bronchi to various stimuli and manifested by widespread narrowing of airways.

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2
Q

How can asthma change in severity?

A

Spontaneously or as a result of therapy

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3
Q

What causes the airways to become inflamed?

A

The immune system

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4
Q

What does the increased airway reactivity cause?

A

Airway narrowing - resulting spontaneously or from stimuli

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5
Q

What is the prevalence of asthma?

A

Children 10 - 15% M > F

Adults 5 - 10% F > M

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6
Q

What are the genetic risk factors for asthma?

A

Atopy

  • Inherited tendency to IgE response to allergens

Asthma, eczema, hayfever, food allergy Markers, skin prick tests, IgE

Strongest risk factor: personal, familial atopic tendency - Maternal atopy most influential (3x father)

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7
Q

What allergens can occupation expose you to?

A

Isocyanates (paints)

Colophony (welding solder flux)

Laboratry Animals

Grains

Enzymes

Drugs

Crustaceans

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8
Q

What are the symptoms of Asthma? (5)

A

Wheeze

Shortness of breath

Chest tightness

Cough paroxysmal,

usually dry Sputum

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9
Q

What are typical triggers?

A

Exercise,

cold air,

smoke,

perfume,

URTI’s,

pets, tree, grass pollen, food, aspirin

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10
Q

What type of variation in asthma might help determine the trigger?

A

Daily Weekly - Occupation, weekends? Holidays? Annual Variation (environmental allergens)

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11
Q

What are essential investigation for asthma diagnosis?

A

Airflow obstruction Variability and reversibility of airflow obstruction

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12
Q

What is the effect of maternal smoking on FEV1?

A

FEV1 ia reduced

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13
Q

What is the effect of maternal smoking on Wheezy illness, airway responsiveness, asthma and severity?

A

All increase

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14
Q

What is known as the Grandmother effect?

A

Grandchildren are far more likely to suffer from asthma if their grandmothers smoked while pregnant.

Mouse work suggests epigenetic modification of oöcytes

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15
Q

What are the three proven risk factors?

A

Smoking

genetics

occupation

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16
Q

What are possible risk factors for asthma? (5)

A

Obesity

diet

reduced exposure to microbes/microbial products

indoor pollution

environmental allergens (house dust mite, cat, grass pollen)

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17
Q

What is body mass index positively associated with?

A

Asthma

Wheezing

Airway hyperactivity

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18
Q

Which diet substances affect risk of asthma?

A

Decrease in anti oxidants and N-3 polyunsaturated fatty acids = risk factor

Increase in N-6 polyunsaturated fatty aids = risk factor

Too much or too little vitamin D

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19
Q

Where might a child be born who has a smaller risk of developing asthma?

A

Farms - increased exposure to microbes and microbial products on the farm

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20
Q

Give an example of microbial products

A

Endotoxin,

glucans,

extrascapular polysaccharide

(Microbial diversity also important in redusing risk of asthma and allergy)

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21
Q

Which indoor cleaning products have an increased risk of causing cancer?

A

Volatile organic compounds

Formaldehyde

Fragrances

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22
Q

What feature of the dust mite is allergenic?

A

Protease in droppings

23
Q

What influence does affluence have on allergens?

A

Increases the likelihood of sensitisation to local allergens

24
Q

What is the most important consideration when making an asthma diagnosis?

A

HISTORY

25
Q

What are the symptoms of asthma?

A

WHEEZE

Dyspnoea

Chest tightness

Cough, usually dry

Sputum

26
Q

What are the common triggers for asthmatics?

A

Exercise

Cold air

Smoke

Perfume

URTI’s

Pets

Tree

Grass

Pollen

Food

Aspirin

27
Q

What type of time variation exists in asthmatics?

A

Daily variation

Weekly variation (occupation will usually be the cause - weekends are when the employee isn’t working)

Annual variation (environmental allergens)

28
Q

What common health conditions are important to consider when diagnosing asthma?

A

Childhood asthma, bronchitis

eczema

hayfever

Hayfever and eczema are other atopic conditions

29
Q

What features of drug use are important to consider when diagnosing asthma? (5)

A

Current inhalers (technique, dosage, compliance)

Beta blockers

Aspirin

NSAIDS (Nonsteroidal anti-inflammatory drugs)

Effects of previous drugs

30
Q

FMH

A

Atopic disease

31
Q

What aspects of socail history are important to consider when diagnosing asthma?

A

Smoking

Pets

Occupations past/present

Psychosocial aspects - Psychosocial profile can affect asthma

32
Q

When is it unlikely to be asthma?

A

Cervical lymphadenopathy (swollen lymph nodes)

Stridor

Assymetrical expansion

Dull percussion note (lobar collapse, effusion)

Crepitations - crackling or rattling sounds) (bronchiectasis, CF, alveolitis, LVF)

33
Q

What are the two positive findings for asthma?

A

Airflow obstruction

Variability and or reversibility of airflow obstruction

34
Q

How can you determine if someone has obstructed airways?

A

FEV1 is less then 80% predicted

FEV1/FVC ratio<70%

35
Q

What do FEV1 and FVC tell us respectively?

A

Airway diameter

Lung Capacity

36
Q

After confirmation of obstructed airways, what is your next steo in the diagnosis of asthma?

A

Full pulmonarty funciton tests,

confirmation of reversibility with B2 agonists and steroids

37
Q

If airways are not obstructed what is your next step in diagnosis?

A

Peak flow monitoring

Bronchial provocation with notric oxide

38
Q

What is a bronchial provocation test?

A

Evaluates how sensitive the airways in your lungs are. The spirometry results are compared before and after you inhale a spray to see what changes there are in your breathing. Spray is usually metyhacholine.

39
Q

What is the purpose of full pulmonary funciton testing?

A

Excluding COPD and emphysema

40
Q

What are the tests involved in the full pulmonary funciton testing?

A

Lung volumes

Carbon monoxide gas transfer

41
Q

What is gas trapping?

A

Abnormal retention of air in the lungs where it is difficult to exhale completely

Observed in obstructive lung diseases such as asthma, bronchiolitis obliterans syndrome and chronic obstructive pulmonary diseases such as emphysema and chronic bronchitis.

42
Q

How is lung residual volume measured of the lungs?

A

Helium dilution technique

The patient inhales breaths of helium and oxygen in a closed system. Concentration of helium will decrease as it diffuses into all areas of the lung. The amount of concentration reduction it indicative of the residual capacity

43
Q

What is the residual volume and total lung capacity of a patient who is asthmatic?

A

Increased residual volume

Increased total lung capacity

RV/TLC > 30%

44
Q

What is the carbon monoxide gas transfer used to determine?

A

Ability of gas transport across the alveoli, alveoli are unaffected in asthma it is only the airway that are affected.

45
Q

When will there be no response to bronchodilator?

A

When there is no bronchoconstriction or severe bronchoconstriction

46
Q

When spirometry is normal why is it important to measure peak flow?

A

Looking for variability in airflow obstruction

Lung function in clinic may(usually) be normal

47
Q

What test is likely to increase use of according to NICE?

A

Exhaled nitric oxide tests

48
Q

How would you read the methacholine responsiveness?

A

Reduction of FEV1 by over 20%

49
Q

What is the effect of methachoine?

A

Acts like acetylcholine to constrict airways

Nebulising the substance you think they are susceptible to can be useful too.

50
Q

What is the exhaled nitric oxide in an asthmatic patient compared to normal?

A

Increase in nitric oxide

51
Q

What are the other useful investigations?

A

Chest X-ray - Hyperinflated, hyperlucent (lung or portion thereof is less dense than normal, as from air trapping by a bronchial foreign body)

Skin prick testing (atopic status)

Total and specific IgE (atopic status)

Full blood count

Eosinophilia (atopy

52
Q

What are the most important considerations when diagnosing acute asthma?

A

Objective > subjective

Ability to speak

Heart rate

Respiratory rate

PEF (peal expiratory flow)

Oxygen saturation / arterial blood gases

No need for pulsus paradoxus (also paradoxic pulse or paradoxical pulse, is an abnormally large decrease in systolic blood pressure and pulse wave amplitude during inspiration)

53
Q
A

Y1Systems (24 decks)

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