Asthma Flashcards

1
Q

General Information

A

Inflammation & bronchoconstriction → airway obstruction & expiratory airflow limitation

Classic Symptoms: Recurrent wheezing, breathlessness, chest tightness & cough

Reversible: If FEV ↑12% with medication |

Exacerbations: Can be mild, severe or fatal

Triggers: Allergens, dust |

Smoke, chemicals, weather |

Lifestyle: Stress/exercise |

Med: ASA, NSAID, BB | Respiratory infections |

Comorbidity: Allergy, GERD, Obesity, Sleep apnea, Anxiety, Depression

Diagnosis: Spirometry; tests forced vital capacity in 1 second to assess expiratory volume: FEV1/FVC

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2
Q

Asthma Tx Algorithm

A
  1. Classify asthma severity → 2. Initiate treatment
  2. F/U 2-6 wks: Review and determine if asthma is under control: step-up, maintain, down. Assess adherence, counsel, control risks, triggers, comorbids:

Avoid: Smoking, Triggers |

▪Exercise: Even if EIB | Vaccines: Flu, Pneumovax 23

  1. Follow up 1-6 months if controlled
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3
Q

Guide to Spacers & Nebulizers

A

Spacers: Open tubes btwn mouthpiece & MDI for kids, dexterity issue,↓thrush |

Clean: QW in warm water

Nebulizer: Liquid med → mist & inhaled thru face mask w/natural breathing.

Two types: Jet & ultrasound

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4
Q

General guidance of Inhaler use

A

> 1 Inhalation: Wait 60 sec between each inhalation > 1 Inhaler: Sequence = SABA → LABA/LAMA → ICS

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5
Q

Asthma in Pregnancy

A

SABA is a must; Preferred controllers: budesonide (ICS)

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6
Q

Peak Flow Meters

A

Monitor asthma control [Peak expiratory flow rate] QAM before meds|

Clean: QW

Essential: Technique & best effort

Blow HARD & FAST

Record highest of 3 attempts

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7
Q

Peak Flow Meter Color Guides

A

% of Personal best

Green > 80 - 100%

Yellow: 50-80% → Action Plan

Red: < 50% → ER

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8
Q

Exercise Induced Bronchospasm (EIB)

A

Preferred preventative: SABA 2 inh 5-15 mins before exercise lasts 2-3hrs

▪ Longer duration: salmeterol (LABA) 30mins before*

*Do not use if already using for asthma maintenance.

▪ Alternative: montelukast taken 2hr prior lasts >24hr

*EIB is often a marker for inadequate asthma control

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9
Q

Classifying Asthma Severity

A
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10
Q
  1. Initiate Tx
A
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11
Q
  1. Asthma Control
A
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12
Q

Dry Powder Inhalers (DPI)

A

Diskus, Ellipta, Pressair, Handihaler, Neohaler, RespiClick, Flexhaler

Delivery: Fine powdered medication NO propellant |

Admin: QUICK & FORCEFUL (no buttons)

Do NOT shake | No priming (Except Flexhaler)

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13
Q

Advair Diskus Instructions

A
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14
Q

Pulmicort Flexhaler Instructions

A
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15
Q

ProAir and Airduo RespiClick

A
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16
Q

Metered Dose Inhalers - Key Features

A

HFA, Respimat or no suffix

Aerosolized liquid med w/propellant: HFA, CFC

Admin: SLOW & DEEP while pressing canister ▪

Spacer: PTs unable to coordinate breathing & pressing

Shake well: except QVAR RediHaler, Alvesco & Respimats

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17
Q

Metered Dose Inhalers - Counseling

A
  1. Shake inhaler for 5 seconds before use ▪except QVAR RediHaler/Alvesco
  2. Breathe out fully
  3. Inhale SLOW & DEEP while pressing top of canister with index finger
  4. Hold breath 10s or as long as possible
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18
Q

Ventolin HFA & ProAir HFA Priming Instructions

A

Spray 4x (3 for Proair) away from face while shaking

▪Prime if > 14 days since last use or drop

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19
Q

Flovent HFA & Dulera Priming Instructions

A

Spray 4x away while shaking.

▪ Prime: 1 spray if > 7 days last use | > 5 for Dulera

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20
Q

Symbicort Priming Instructions

A

Spray 2x while shaking.

▪ Prime if > 7 days last use

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21
Q

Ventolin HFA & ProAir HFA Cleaning Instructions

A

Remove metal canister & rinse mouthpiece with warm H2O, then air dry. (1x/wk)

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22
Q

Flovent HFA Cleaning Instructions

A

Clean cotton swab w/H2O to clean where med sprays. Air dry.

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23
Q

Dulera & Symbicort Cleaning Instructions

A

Do NOT put in water. Use clean, dry cloth to wipe inside and outside of mouthpiece.

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24
Q

SAMA - Description

A

Inhibits cholinergic: Bronchodilation | acute exacerbation

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25
SAMA agents
Ipratropium
26
SABA - Description
Rescue therapy for ALL patients
27
ProAir HFA
Albuterol
28
Respiclick
Albuterol
29
Proventil
Albuterol
30
Ventolin
Albuterol
31
Xopenex Concentrate Xopenex HFA
Levalbuterol
32
Asthmanefrin Refill
Racepinephrine
33
Treatment Algorithm
34
Primatene Mist
Epinephrine
35
Albuterol Key features
90 mcg/inh | Most 200 inh; Ventolin (some): 60 inh MDI/DPI: 1 - 2 inh Q4-6H PRN
36
Levalbuterol Key features
R-isomer of albuterol
37
Racepinephrine key features
Non-selective - do not use
38
Epinephrine key features
FDA: Mild, intermittent
39
SABA - Safety
ADR: Nervousness, tremor, tachycardia, palpitations, cough, hyperglycemia, ↓K
40
ICS Description
1st line for ALL patients: Inhibits inflammatory response: ↓sx, ↑lung function, ↑QOL and ↓exacerbations.
41
QVAR Redihaler
Beclomethasone
42
Pulmicort Flexhaler Pulmicort Respules
Budesonide
43
Flovent HFA Flovent Diskus
Fluticasone
44
Arnuity Ellipta
Fluticasone
45
Alvesco
Ciclesonide
46
Aerospan
Flunisolide
47
Twisthaler
Mometasone
48
Asmanex HFA
Mometasone
49
QVAR Redihaler - Key features
NO shaking
50
51
Which is the only ICS that can be nebulized?
Budesonide
52
Pulmicort respules - key features
Budesonide Only use with jet nebulizer
53
Alvesco - key features
Ciclesonide No shaking
54
ICS - Safety
ADR: Dysphonia (difficulty speaking), Thrush\*, Cough \*Prevention: Rinse mouth & throat or use spacer
55
LABA agents
Salmeterol
56
Serevent Diskus
Salmeterol
57
Salmeterol - Key features
Not for acute bronchospasm NEVER use alone
58
Salmeterol - Safety
BBW: ↑risk of asthma related death: only use if also receiving a long-term control (ICH) but not adequate
59
Spiriva Respimat
Tiotropium
60
ICS + LABA Steps 1-5
Symbicort Dulera
61
ICS + LABA Steps 1-5 Key features
Doses: Low, Medium, and High
62
ICS + LABA: Steps 3-5
Advair Diskus HFA AirDuo Wixela Inhub Breo Ellipta
63
ICS + LABA: Steps 3-5 - key features
Doses: Medium and High
64
Symbicort
Budesonide + Formoterol
65
Dulera
Mometasone + Formoterol
66
Advair Diskus Advair HFA
Fluticasone + Salmeterol
67
AirDuo
Fluticasone + Salmeterol
68
Wixela Inhub
Fluticasone + Salmeterol
69
Breo Ellipta
Fluticasone + Vilanterol
70
Singulair
Montelukast Available as tab, chew, and packet
71
Montelukast description
Inhibits leukotriene D4 (LTD4)
72
Accolate
Zafirlukast
73
Zafirlukast description
Inhibits both LTD4 and LTE4
74
Zyflo Zyflo CR
Zileuton
75
Zileuton description
5-lipooxygenase inhibitor: Inhibits leukotriene formation
76
Singulair - Key features
6 - 14yo: 5mg QPM | 1 - 5yo: 4mg QPM Granules: Admin directly → mouth/mixed. Use 15min of opening
77
Accolate - key features
Dispense in original container
78
Leukotriene Modifying Agents - Safety
Warning: Neuropsych events
79
Theophylline description
Blocks phosphodiesterase → ↑cAMP → EPI release → bronchodilation but also diuresis, CNS & cardiac stim
80
Theo-24
Theophylline
81
Theochron
Theophylline
82
Elixophyllin
Theophylline
83
Theophyllin - key features
Active metabolite: caffeine Conversion: Aminophylline → Theophylline x 0.8 [ATM]
84
Theophylline - safety
Toxicity: persistent vomiting, arrhythmia, seizures
85
Xolair
Omalizumab
86
Omalizumab description
Inhibits IgE for \> 6yo if +skin test & ICH inadequate Indication: Severe Allergic Asthma
87
Xolair key features
Admin: SC q2-4w healthcare MD supervision
88
Omalizumab safety
BBW: Anaphylaxis
89
Interleukin Receptor Antagonists - Eosinophilic phenotype
Mepolizumab Reslizumab Benralizumab Dupilumab
90
Nucala
Mepolizumab
91
Cinqair
Reslizumab
92
Fasenra
Benralizumab
93
Dupixent
Dupilumab
94
Xolair key features
Admin: SC q2-4w healthcare MD supervision
95
Nucala key features
SC Q4w
96
Cinqair key features
IV Q4w
97
Fasenra key features
SC Q4w for 3 doses then Q8w
98
Dupixent key features
SC QoW
99
Cinqair - Safety
BBW: Anaphylaxis