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Lung > Asthma > Flashcards

Asthma Flashcards

1
Q

Diphenhydramine and chlorpheniramine are what type of drug?

A

1st gen Anti-histamine

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2
Q

Fexofenadine, Cetririzine, and Loratadine are what type of drug?

A

2nd gen Anti-histamine

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3
Q

1st vs. 2nd gen Anti-histamine

A

Second gen are more specific and do not actively cross the BBB decreasing sedation, anti-muscarinic and anti-cholinergic effects

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4
Q

Aminophylline and Theophylline act by what mechanism?

A

Methyl-xanthines that inhibit phosphodiesterase increasing cAMP and blocking Adenosine

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5
Q

What is replacing Theophyilline for treatment and why?

A

LKT antagonists do not have the narrow therapeutic index of theophylline

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6
Q

What drug is a mast cell stabilizer?

A

Cromolyn

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7
Q

How is cromolyn usually delivered?

A

Nasal Spray
Or Oral
Or inhaled

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8
Q

Pseudoephedrine does what?

A

a-agonist reducing nasal congestion, edema, and hyperemia

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9
Q 
Prednisone
Methylprednisolone
Dexamethasone
Betamethasone
Delivered how and used for what?
A

Oral/IV delivery to suppress severe active attacks

Pre MeD Be Severe

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10
Q

Corticosteroids inhaled to prevent asthma attacks?

A 
Triamcinolone
Beclamethasone
Flunisolide
Budesonide
Fluticasone
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11
Q

Omalizumab MOA and delivery?

A

Subcutaneous injections of a MAB that inhibits IgE binding to FCeRI

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12
Q

Short acting B2 agonists?

A

Albuterol

Pirbuterol

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13
Q

Long acting B2 agonists?

A

Fometerol

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14
Q

Zileuton MOA?

A

Inhibits 5LO

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15
Q

Montelukast and Zafirlukast MOA?

A

Competitive agonist of CysLKTR

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16
Q

Treatment for Intermittent Asthma?

A

Rescue inhaler only (SABA)

17
Q

TX for mild persistent asthma?

A

SABA + Low dose Inhaled Corticosteroid (ICS)

Alternative: Cromolyn LKT inhbitors

18
Q

TX for moderate persistent asthma?

A

SABA + Low dose ICS + LABA

Alternatives: Medium dose ICS, Low dose ICS + other options

19
Q

TX for Moderate-Severe persistent asthma?

A

Medium Dose ICS + LKT antagonist

Alternatives: Medium Dose ICS + Other options

20
Q

Tx for severe persistent Asthma?

A

High dose ICS + LKT antagonist

Omalizumab

Lung (6 decks)

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