Asthma Flashcards

1
Q

What is the most frequently used beta-agonist in a rescue inhaler?

A

•Short-acting beta-2 agonists: Albuterol, levalbuterol.
•Long-acting beta-2 agonists: Formoterol, salmeterol, indacaterol.
•Beta-1 agonists: Dobutamine, norepinephrine (noradrenaline), dopamine (in high doses).
•Beta-1 and beta-2 agonists: Epinephrine (adrenaline), isoproterenol.

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2
Q

How does a beta-agonist work? (Trashy card)

A

by attaching to (binding) beta-receptors — “activators” in or on your cells that unlock certain functions

engaging the beta-2 adrenergic receptors on smooth muscle of bronchial tissue, relieving bronchospasm and reducing airway resistance

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3
Q
  1. How does a beta agonist work
A

Quickly relax bronchial muscles causing bronchospasm.

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4
Q

Examples of SABA (short action beta agonist)

A

Albuterol administered in the brands ProAir™, Proventil™, and Ventolin™

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5
Q
  1. How often can a rescue inhaler be used to relieve asthma symptoms?
A

Twice a week

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6
Q

Superior to inferior structures of the respiratory system

A

pharynx, Larynx , trachea, bronchi, bronchioles

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7
Q

Boyle’s law states that in a closed space, pressure and volume are ________ related

A

Inversely

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8
Q

During inhalation, volume in the thoracic cavity __________ which causes a ___________ in pressure

A

Enlarge, down

(As volume goes up, pressure goes down)

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9
Q

During exhalation, the thoracic cavity _______, which causes a __________, in pressure

A

Decrease in volume, increase

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10
Q

Describe the role of surfactant in the lungs

A

-Reduced surface tension
-break down hydrogen bonds in water for expansion of alveoli
-secreted by Type II alveolar cells (t2 pneumocytes)

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11
Q

What lung volume is most affected in a patient with asthma?

A

Expiratory volume

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12
Q

How often can a rescue inhaler be used help alleviate asthma symptoms?

A

One or two inhalations can be taken every four to six hours

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13
Q

How does a beta-agonist work?

A

Relax bronchial smooth muscle, opening the airway allowing more oxygen as you breathe

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14
Q

What is asthma?

A

Chronic long-term lung disease that inflames and narrows the airways. The airways react strongly to inhaled substances making them swollen and sensitive. Constricting muscle around airways and mucus plug up bronchi

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15
Q

Symptoms of asthma

A

-wheezing
-coughing
- chest tightness
- SOB

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16
Q

How many in US with asthma?

A

+25 million

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17
Q

What factors put asthma at risk?

A

genetic and environmental factors
-parents
-children (6)
-allergies
-eczema
-obesity

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18
Q

What environmental agents trigger an attack?

A

-dust
-animals
-mold
-pollen
-smoke
-pollution
-chemicals
-aerosols
-medication (aspirin NSAIDS)
-exceecise

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19
Q

How long does an attack last?

A

A few minutes to a few days

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20
Q

Who mentioned asthma earliest?

A

Homer in the Iliad
(Asthma is a sharp breath)

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21
Q

Stimuli that cause asthma

A

Early childhood infection, chemical exposure, insufficient immune system

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22
Q

What does a peak flow meter measure?

A

Peak flow meter measures How air flows from your lungs in a fast blast

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23
Q

Why use peak flow measurement regularly?

A

Indications of worsening asthma before the patient detection. Determine severity of episode. When to use inhaler and when to get care.

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24
Q

Steps to using peak flow meter

A
  1. Slide marker to bottom of scale
    2.stand up straight and breathe in deeply than out fast and hard
  2. note the number
  3. Repeat 3 times
  4. Record highest
    *tou can breathe out too little
  5. Measure same time each day
  6. Keep chart
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25
Q

What is “personal best”?

A

Highest of 3 ratings when normal breathing

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26
Q

What are three zones commonly used to interpret peak flow rates?

A

traffic light
green zone: 80-100%
yellow zone: 50-80%
red zone: less than 50%

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27
Q

RED ZONE

A

Less than 50%
SOB
Quick relief doesn’t help or yellow zone for too long

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28
Q

YELLOW ZONE

A

50-80%
Airways are narrowing. follow action plan
- coughing / wheezing
SOB
Waking at night

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29
Q

GREEN ZONE

A

Usual activities can be performed

30
Q

SABA

A

Short acting beta agonist

31
Q

ICS

A

Inhaled corticosteroids

32
Q

LABA

A

Long acting beta agonist

33
Q

Oral corticosteroids

A

Reduce severe inflammation

34
Q

SABA def

A

Relaxes bronchial muscles causing bronchospasm

Flare ups, rescue inhaler, quickly

35
Q

ISC def

A

Reduce inflammation in lungs and reduce mucus mucus production

1st med

36
Q

LABA def

A

Bronchidialators

(Dialate airways)

37
Q

Oral corticosteroids

A

Reduce severe inflammation

Exacerbation
Short term

38
Q

Physician

A

Diagnose and treat individuals and address health maintenance

39
Q

Primary care physician

A

Family medicine
Definitive care to patient and responsibility for comprehensive care
Preventative care

40
Q

Respiratory therapy

A

Educate and treat people with asthma and rehab if long term

41
Q

Emergency medicine

A

Diagnosis and treatment of unforeseen injury

42
Q

Functions of the respiratory system

A

-Maintain pH
-Smell, sound, excretion of heat and water
-gas exchange

43
Q

Epitope of antigen (antigenic epitope)

A

Specific binding site

44
Q

Tidal volume

A

Normal, quiet breathing

45
Q

Inspiratory reserve volume

A

All you can inhale after tidal volume

46
Q

Expiratory reserve volume

A

All air forced out after tidal volume

47
Q

Residual volume

A

Air in lungs after exhale

48
Q

Inspiratory capacity

A

Tidal volume + Inspiratory volume

(All inhaled)

49
Q

Functional residual capacity

A

Sum of Residual volume and Expiratory reserve volume

50
Q

Vital capacity

A

Sum of IRV, ERV, and tidal volume

(Inspiratory reserve volume and Expiratory reserve volume)

51
Q

How do Antibodies fight invaders? (5)

A
  1. Neutralization
  2. Immobilizing bacteria
  3. Agglutination and precipitation of antigen
  4. activating complement
  5. Enhances phagocytosis
52
Q

Antigen Epitope

A

Large parts of antigen that trigger immune response

53
Q

Goblet cell

A

Secrete mucus

54
Q

Respiratory zone

A

Allows for gas exchange

55
Q

Conducting zone

A

Bring air to alveoli
(Filter, warm, moist)

56
Q

Pulmonary ventilation

A

Inhale (inflow) and exhalation (outflow) of air and exchange between atmosphere

57
Q

Type I alveolar cells

A

Site of gas exchange between capillaries

58
Q

Type II alveolar cells

A

Secrete surfactant
(Reduces tension)

59
Q

Exhalation is a

A

Passive process

60
Q

Initial antibody, ten binding sites (5)

A

IgM

(Me first)

61
Q

Most abundant antibody, protects against virus and bacteria, cross placenta

A

IgG

(Generally does a lot)

62
Q

Secretory antibody In body secretions, gland protection

A

IgA

(All the areas to outside)

63
Q

IgD

A

Found on immune cells and acts as antigen receptor

(Deez will find antigen)

64
Q

IgE

A

Allergic reactions and hypersensitivity can kill parasitic worms

(IgE rhymes with sneeze)

65
Q

Immediate (type I) hypersensitivity reactions

A

Allergen induced asthma when b-cells make antibody IgE instead of IgG binding to mast cells / basophils

66
Q

Histamine

A

Causes allergic reaction

67
Q

Leukotrine

A

Prolongs histamine response
Mucus stimulation

68
Q

Symptoms

A

Bronchiospasm, tachycardia, tachypenia, dyspniea, wheezing, chest tightness

69
Q

Peak flow meter

A

Measures max exhale

70
Q

Small volume nebulizer

A

Delivers liquid medication to lungs