Associations to make given a Histologic or Laboratory Finding

Question 1

Usual interstitial pneumonia

Answer 1

Idiopathic pulmonary fibrosis; connective tissue diseases (uncommon); asbestosis; hypersensitivity pneumonitis; chronic aspiration pneumonia; chronic radiation pneumonitis; Hermansky-Pudlak syndrome; neurofibromatosis

Question 2

Nonspecific interstitial pneumonia

Answer 2

iopathic; connective tissue diseases; drugs; hypersensitivity pneumonitis; resolving diffuse alveolar damage; AIDS; infections

Question 3

Diffuse alveolar damage

Answer 3

Acute interstitial pneumonia (Hamman-Rich syndrome); acute respiratory distress syndrome; drugs (cytotoxic agents, heroin, cocaine, paraquat, ethchlorvynol, aspirin); toxic gas inhalation; radiation therapy; oxygen toxicity; connective tissue disease; infections (Legionella, Mycoplasma,viral)

Question 4

Organizing pneumonia

Answer 4

ryptogenic organizing pneumonia; organizing stage of diffuse alveolar damage; organizing infections (e.g., influenza) as part of diffuse alveolar hemorrhage; drugs (amiodarone, cocaine); infections; connective tissue diseases; hypersensitivity pneumonitis; eosinophilic pneumonia; granulomatosis with polyangiitis (Wegener)

Question 5

Desquamative interstitial pneumonia/respiratory bronchiolitis

Answer 5

Cigarette smoking; idiopathic; connective tissue diseases; primary pulmonary Langerhans cell histiocytosis; asbestosis; hard-metal pneumoconiosis (cobalt); Gaucher disease; Niemann-Pick disease; Hermansky-Pudlak syndrome; drugs (nitrofurantoin, amiodarone

Question 6

Lymphocytic interstitial pneumonia

Answer 6

Idiopathic; hypogammaglobulinemia; autoimmune diseases, including Hashimoto thyroiditis, lupus erythematosus, primary biliary cirrhosis, Sjögren syndrome, myasthenia gravis, chronic active hepatitis; AIDS; allogeneic bone marrow transplantation

Question 7

Eosinophilic pneumonia

Answer 7

Idiopathic acute and chronic; tropical filarial eosinophilia; parasitic infections; allergic bronchopulmonary aspergillosis; eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome); hypereosinophilic syndrome; AIDS

Question 8

Alveolar proteinosis

Answer 8

Pulmonary alveolar proteinosis; acute silicosis; aluminum dust; AIDS; myeloproliferative disorder

Question 9

Diffuse alveolar hemorrhage (with capillaritis)

Answer 9

Granulomatosis with polyangiitis (Wegener); microscopic polyangiitis; systemic lupus erythematosus; polymyositis; scleroderma; rheumatoid arthritis; mixed connective tissue disease; lung transplantation; drugs (retinoic acid, propylthiouracil, dilantin); Behçet disease; cryoglobulinemia; Henoch-Schönlein purpura; pauci-immune glomerulonephritis; immune complex glomerulonephritis

Question 10

Amyloid deposition

Answer 10

Primary amyloidosis; multiple myeloma; lymphocytic interstitial pneumonia, lymphoma

Question 11

Granuloma

Answer 11

Sarcoidosis; hypersensitivity pneumonitis; pulmonary Langerhans cell histiocytosis; intravenous talcosis; berylliosis; lymphocytic interstitial pneumonia; infections

Question 12

Leukopenia

Answer 12

Sarcoidosis; connective tissue disease; lymphoma; drug-induced

Question 13

Leukocytosis

Answer 13

systemic vasculitis; hypersensitivity pneumonitis; lymphoma

Question 14

Eosinophilia

Answer 14

Eosinophilic pneumonias; sarcoidosis; systemic vasculitis; drug-induced (sulfa, nitrofurantoin, methotrexate)

Question 15

Thrombocytopenia

Answer 15

Sarcoidosis; connective tissue disease; drug-induced; Gaucher disease; idiopathic pulmonary fibrosis

Question 16

Hemolytic anemia

Answer 16

Connective tissue disease; sarcoidosis; lymphoma; drug-induced; idiopathic pulmonary fibrosis

Question 17

Normocytic anemia

Answer 17

Diffuse alveolar hemorrhage syndromes; connective tissue disease; lymphangitic carcinomatosis

Question 18

Urinary sediment abnormalities

Answer 18

Connective tissue disease; systemic vasculitis; drug-induced

Question 19

Hypogammaglobulinemia

Answer 19

Lymphocytic interstitial pneumonia; granulomatous lymphocytic interstitial lung disease

Question 20

Hypergammaglobulinemia

Answer 20

Connective tissue disease; sarcoidosis; systemic vasculitis; idiopathic pulmonary fibrosis; asbestosis; silicosis; lymphocytic interstitial pneumonia; lymphoma

Question 21

Serum autoantibodies

Answer 21

Connective tissue disease; systemic vasculitis; sarcoidosis; idiopathic pulmonary fibrosis; silicosis; asbestosis; lymphocytic interstitial pneumonia

Question 22

Serum immune complexes

Answer 22

Idiopathic pulmonary fibrosis; lymphocytic interstitial pneumonia; systemic vasculitis; connective tissue disease; pulmonary Langerhans cell histiocytosis

Question 23

Serum angiotensin-converting enzyme

Answer 23

sarcoidosis; hypersensitivity pneumonitis; silicosis; acute respiratory distress syndrome; Gaucher disease

Question 24

Antibasement membrane antibody

Answer 24

Goodpasture syndrome

Question 25

Antineutrophil cytoplasmic antibody

Answer 25

Systemic Vasculitis