Asbestos

Question 1

What is the use of soluble mesothelin related peptide?

Answer 1

Marker of disease activity

Not for diagnostics

Question 2

Asbestosis- related to exposure duration or no?

Answer 2

Directly related to intensity and duration of exposure, usually need over 10 years

Question 3

What does asbestosis look like on radiology?

Answer 3

Irregular/linear opacities
Low–>mid–upper lung
Subpleural linear densities parallel to the pleurae

Question 4

Mesothelioma relationship with exposure?

Answer 4

NOT ASSOCIATED WITH SMOKING
ASBESTOS ONLY KNOWN RF
but can be a short exposure, even 1-2 years

usually die from local extension not mets

Remember pleural OR peritoneal

Question 5

Non mesothelioma lung cancer and risk?

Answer 5

RR 3.5 all types
15-19 year latency post exposure
ADDITIVE effect of smoking

Question 6

Are pleural plaques pre-malignant?

Answer 6

No

Question 7

Other cancers associated with asbestos exposure

Answer 7

larynx
oropharynx
kidney
oesophagus
biliary system