Arterial Disease of the Limbs - Presentation, Investigation & Therapy Flashcards
Name the arteries
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How do you examine for the aortic pulse?
Above umbilicus
Use two hands to feel for pulsation vs expansion
How do you feel for the common femoral artery?
Mid-inguinal point, ½ way between Anterior Superior Iliac Spine and pubic symphysis
How do you feel for the popliteal artery?
Use both hands to feel deep in popliteal fossa – leg relaxed into your hands
How do you find the posterior tibial pulse?
½ way between medial malleolus and achilles tendon
How do you find the dorsalis pedis pulse?
Lateral to extensor hallucis longus tendon
What is the cause of CLI (critical limb ischaemia)?
Atherosclerotic disease of arteries supplying lower limb
What are the risk factors for CLI?
Male
Age
Smoking
Hypercholesterolaemia
Hypertension
Diabetes
What is stage 1 CLA according to the Fontaine classification?
Stage I: Asymptomatic, incomplete blood vessel obstruction
What is stage 2 CLA according to the Fontaine classification?
Mild claudication pain in limb
Stage IIA:
- Claudication when walking more than 200m
Stage IIB:
- Claudication when walking less than 200m
What is stage 3 CLA according to the Fontaine classification?
Stage III: Rest pain, mostly in feet
What is stage 4 CLA according to the Fontaine classification?
Stage IV: Necrosis and/or gangrene of limb
Which leg does claudication usually impact?
Bilateral
What is typical past medical history for CLI?
Other signs of atherosclerosis (MI, Stroke?)
What drug might a CLI patient be taking?
control of diabetes, aspirin
What is the significance of a CLA patient occupation?
Determines type of treatment
What are the signs of chronic ischaemia on examination?
Ulceration
Pallor
Hair loss
What should you feel during examination of CLA?
Capillary refill times
Temperature
Pulses
Peripheral sensation (particularly in diabetics)
Start at toes
Always compare sides
How do you auscultate for CLA?
Hand held doppler (ultrasound machine)
Listening to dorsalis pedis and posterior ribial pulses
What is the ankle brachial pressure index and what does it indicate?
- Ratio of ankle pressure over brachial pressure
- When exercising should be greater than 1 since leg muscles need lots of O2 so increased blood flow.
- At rest ratio should be around 1 less than 1 indicates obstruction of blood flow
What is the buerger’s test?
Elevate legs - pallor below 20 degree angle indicates severe ischaemia
Hang feet over edge of bed - slow to regain colour, should progress to Dark red colour (hyperaemic sunset foot).
Why does hanging feet over the edge of a bed cause CLI patients’ feet to become hyperaemic?
Normally only 1/3 of capillaries are open
In CLI all capillaries are open and autoregulation is lost
What is peripheral vascular disease treated the same way as?
Should be managed the same way as those with established CHD
What is best medical therapy?
Antiplatelet
Statin
BP control: Target <140/85
Smoking cessation
Exercise: 150% improvement in walking time – body develops own collaterals with neo-angiogenesis
Diabetic control: 10% of PAD patients are undiagnosed diabetics, Tight glycaemic control prevents microvascular disease
(Statins Inhibit platelet activation and thrombosis, endothelial and inflammation activation, plaque rupture)
What type of therapy is best for
- Moderate symptoms
- Severe symptoms
- Critical symptoms
Moderate - BMT only
Severe - BMT, angioplasty/stent, surgical bypass
Critical - BMT, angioplasty / stent / endovascular reconstruction / surgical bypass
What are the possible imaging investigations for CLI?
CT/MRA
Digital subtraction angiogram (angiography)
Duplex - (ultrasonography where structure or architecture of body part is captured and flow or movement of a structure is visualised)
What are the advantages and disadvantages of Duplex?
Advantages:
Dynamic – assess flow as well as anatomy
No radiation/contrast
Disadvantages:
Not good in abdomen (iliacs)
Operator dependent, time consuming
What are the benefits of CT/MRA
Advantages:
Detailed – allows treatment planning
First line according to NICE
Disadvantages:
Uses Contrast and Radiation
Can overestimate calcification, difficulty in low flow states (difficult if there is terrible heart failure and the contrast can’t really reach the feet)
What are the possible conduits for surgical bypass?
Reversed saphenous vein
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What does surgical bypass require?
Inflow
A conduit
Outflow
Why is an autologous conduit better than a synthetic one?
Synthetic has higher risk of infection
What are the general risks / complications of surgical bypass?
Bleeding
wound infection
pain
scar
DVT/PE
MI
stroke
death (2%)
What are the technical risks / complications of surgical bypass?
Damage to nearby vein, artery, nerve, distal emboli, graft failure (stenosis, occlusion)
What is reintervention rate for surgical bypass?
18 – 39% (higher if smoking)
(18.3-38.8%)
What are 5 year patency rates of surgical bypass?
45-73%
What are the types of amputation from the hip down?
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Which type of amputation requires more energy?
BKA or AKA (above or below the knee amputation)
63% higher in BKA
117% higher in AKA
What are the different ways an embolus can arise?
MI, AF, proximal atherosclerosis (not DVT/PE these are linked to venous disease)
Trauma
Dissection
Acute aneurysm thrombosis
What is the point in finding out the onset/duration of symptoms?
Lets you know the likely prognosis
What are the 6 P’s of presentation?
Pain
Pallor
Perishingly cold
Paraesthesia
Paralysis
Pulseless
Compare to contralateral limb
What is compartment syndrome?
Swelling or bleeding occurs within a compartment
Fascia doesn’t stretch, increases pressure on capillaries, nerves, and muscles
Blood flow to muscle and nerve cells is disrupted
Without steady O2 and nutrient supply, nerve and muscle cells can be damaged
In this case what causes the acute compartment syndrome?
After surgeon repairs damaged blood vessel that has been blocked for several hours.
Rise in creatine kinase - risk of renal failure since creatine is massive
What is management of acute limb ischaemia?
ECG, bloods, nil by mouth
Analgesia
Anticoagulate (heparin - allows chance of blood getting through occlusion)
What is management of a salvagable limb in ALI management?
Embolus - embolectomy
Thrombus - Endovascular: mechanincal thrombectomy/thrombolysis or open embolectomy +/- bypass
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What type of anaesthetic is used for embolectomy?
General or local
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What is the likely cause for ALI?
30% embolic, 60% thrombosis in situ
When does irreversible muscle ischaemia occur?
In 6-8 hours
What is the pathophysiology of diabetic foot disease?
Microvascular peripheral artery disease
Peripheral neuropathy – lost sensation in foot – more likely chance of trauma
Mechanical imbalance – lost proprioception and walk differently – pressure points different and damaged
Susceptibility to infection
How do you ensure footcare of a diabetic?
Always wear shoes
Check fit of footwear
Check pressure points of foot regularly
Prompt and regular wound care
What is diabetic foot management?
- Prevention
- Good wound care
- Tracking infection (lymphangitis or cellulitis)– consider systemic antibiotics
- Investigate for osteomyelitis, gas gangrene, necrotising fasciitis
- Revascularisation
- Disease is very distal – attempt distal crural angioplasty / stent
- Distal bypass
- Amputation