Arrhythmias Therapy Flashcards

1
Q

What is class I of the Vaughan-Williams antiarrhythmic drug classification?

A

Sodium channel blockers

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2
Q

What is the mechanism of action of sodium channel blockers?

A

Membrane stabilising agents, act principally by suppressing excitability and slowing conduction in atrial or ventricular muscle

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3
Q

What are the class Ia drugs? How do they work?

A

Quinidine
Disopyrmaide

Block sodium channels and prolong AP

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4
Q

What are the class Ib drugs? How do they work?

A

Lidocaine
Mexiletine

Block sodium channels and shorten AP

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5
Q

What are the class Ic drugs? How do they work?

A

Flecanide
Propafenone

Block sodium channels, no effect on AP

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6
Q

What is class II of the Vaughan-Williams antiarrhythmic drug classification?

A

Beta blockers

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7
Q

What are the class II drugs?

A

Atenolol
Bisoprolol
Metoprolol
L-sotalol

Beta-adrenoceptor antagonists

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8
Q

What are the class III Vaughan-Williams antiarrhythmic drugs?

A

Amiodarone

D-sotalol

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9
Q

What is the mechanism of action of the class III drugs?

A

Main effect is to prolong the AP - act by prolonging the plateau phase of the AP, thus lengthening the refractory period

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10
Q

What is class IV of the Vaughan-Williams antiarrhythmic drug classification?

A

Slow calcium channel blockers

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11
Q

What are the class IV drugs?

A

Verapamil

Diltiazem

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12
Q

What is the mechanism of action of the class IV drugs?

A

Block the slow calcium channel which is particularly important for impulse generation and conduction in atrial and nodal tissue

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