ARBs Flashcards
1
Q
What is the site of action of the ARBS?
A
Angiotension II (AT1) receptors.
2
Q
What is the MOA of ARBS?
A
Competitive binding to inhibit the action of angiotension II at it’s receptor without affecting ACE activity.
3
Q
What does the blockade of the Angiotension II (AT1) receptor result in?
A
Decreased peripheral vasoconstriction and blocked aldosterone secretion.
4
Q
How do the SE of ARBS compare to ACEI?
A
They are about the same. A little less cough is noted int the ARBS.
5
Q
SO then what again are the side effects of ACEI (which can now also be thought as the SE of ARBS?)
A
Granulocytopenia Angioedmema Proteinuria Prolonged hypotension Upper respiratory congestion rhinorrhea.
6
Q
Do ARBs have an effect on ACE or cause bradykinin accumulation?
A
NO
7
Q
When are ARBs contraindicated?
A
Renal artery stenosis
Pregnancy
8
Q
What is common about the ARBs name?
A
they all end in “sartan” yay!
