ACEI DRUG SPECIFIC

Question 1

What is the prototype ACEI?

Answer 1

Captopril

Question 2

What is the dose of Captopril?

Answer 2

12.5 to 25mg q 8 hours.

Question 3

Onset of captopril?

Answer 3

15 minutes.

Question 4

E1/2T of captopril?

Answer 4

2 hours.

Question 5

What kind of effect does captopril have?

Answer 5

Decreases SVR, does not affect SNS outflow…

Question 6

What kind of side effects does captopril have?

Answer 6

Rash, loss of taste, antagonizes the effects of NSAIDs, hyperkalemia and angioedema.

Question 7

What is different about Enalapril as compared to captopril?

Answer 7

Enalapril is a pro drug (meaning it has to be metabolized first). Compared to captopril it lacks a sulfhydryl group thus does not cause the rash and renal insuff caused by captopril.

Question 8

How is Enalapril given?

Answer 8

IV

Question 9

What kind of form is lisinopril administered in? And how is it excreted?

Answer 9

Administered in an active form.

Excreted unchanged in the kidney.

Question 10

So which of the ACE inhibitors is a prodrug?

Answer 10

Enalapril.

Question 11

List the three ACEI in order of their onset effect quickest to slowest?

Answer 11

1. Captopril (15-30 minutes)
2. Lisinopril (60 minutes)
3. Enalapril (60-120minutes)

Question 12

List the three ACEI in order of there time of peak action?

Answer 12

1. Captopril (1-2 hours)
2. Lisinopril (2-4 hours)
3. Enalapril (4-8 hours)

Question 13

List the three ACEI in order of there duration of effect?

Answer 13

1. Captopril 6-10 hours
2. Lisinopril 18-30 hours
3. Enalapril 18-30 hours

Question 14

All of the ACEI work more on which the venous or arterial system?

Answer 14

Arterial.