Arboviruses Flashcards
Arboviruses are ________-borne viruses: vectors are usually ______ and _____.
All contain RNA/DNA? and All are enveloped/ unenveloped?.
T or F humans are not dead end hosts?
Arthropod; Mosquitoes and ticks.
RNA; Enveloped
False; humans Are dead end hosts.
Outcome of arbovirus depends of 3 things
1) specific viral agent
2) age of patient
3) Extent to which encephalitis develops.
Diagnosis of Arbovirus:
____ antibody capture ELISA.
_____ sample is the easiest.
IgM antibody.
can also add virus-specific monoclonal antibodies to increase specificity.
CSF.
Culture of arbovirus is NOT/ VERY typical?
Not
How come NAT testing of Reverse transcriptase-based PCR of RNA genome of Arbovirus not reliable in acute phase?
Viremia is ofter weak and transient.
To ensure further viral transmission of arbovirus the animal must have a titer higher than______.
10^4.
1) Humans are tangetial hosts accidentally entering a natural zoonotic transmission cycle.
2) Large human population coexisting with large vector population such as mosquitoes?
Which one is Sylvatic cycle and which is Urban Cycle?
1) Sylvatic
2) Urban
Encephalitis definition
S/S’s indicating involvement of brain parenchyma
Seizures, alteration of consciousness, visual disturbances, paralysis of extremities.
What are the long term deficits in children after ARbovirus?
Deafness
Psychomotor difficulties
Learning disabilites
WEE vector is most active where and when?
Rural areas and at sunset
EEE and VEE vectors are active when?
Daytime
The Togaviridae is ___veloped; ss (__)RNA.
Where does replication take place?
enveloped; +
Cytoplasmic replication.
What are the 3 encephalitis’s and 1 fever under The Flaviviridae?
3) St. Louis/ West Nile/ Japanese
1) Yellow Fever.
What is the genome of the Bunyaviridae?
What are the two physical features of the Bunyaviridae?
3 circular segments of ss(-) RNA
It is enveloped and Spherical.
What is the Encephalitis associated with the Bunyaviridae?
California Encephalitis.
