APS136 3 Flashcards
An adaptation is..
a trait that increases the fitness of an organism in its environment (increases chance of survival)
- trait is selected for
- genetically determined, therefore heritable
Camels can go without water for … … and without food for … …
2 weeks,
2 months
Acclimation is…
a physiological compensatory response to environmental change (experimental) - a short-term response to the environment
- not heritable
- may be immediate or build up over time
- experimental
- e.g. yoga in unnaturally hot room or moving fish into new water
Acclimatisation is..
a physiological compensatory response to environmental change (natural) - a short-term response to the environment
- not heritable
- may be immediate or build up over time
- natural
- e.g. acclimatising to naturally hot outside conditions (rather than unnatural lecture theatre conditions)
Plasticity is…
the ability of living organisms to change their ‘state’ in response to any stimuli
- occurs at any level of complexity: molecular, cellular, systemic and behavioural
- limited
- e.g. rockhopper penguins
At high altitudes there is low … … and low … …
barometric pressure
atmospheric oxygen
The concentration of oxygen at 4000m is about … lower than at sea level
40%
Each haemoglobin molecule has … oxygen binding sites
4
Normal oxygen saturation is between…
96-100%
- oxygen saturation is the % of haemoglobin binding sites that carry oxygen
At low partial pressures of oxygen, e.g. in the body tissues, Hb has … …, so oxygen is …
low affinity,
released
At high partial pressures of oxygen, e.g. in the lungs, Hb has … …, so oxygen … ….
high affinity,
binds readily
At high altitudes (with low oxygen saturation), you can suffer from … and the oxygen transport system must respond to…
hypoxia,
maintain sufficient tissue oxygen concentration
The Andeans in Bolivia have been living at high altitudes of 4000m for…
13,000 years
A population of Tibetans have been living at altitudes of 4000m for…
25,000 years
High-altitude erythrocytosis is…
increased red blood cell production at high altitudes
Andeans had … Hb concentrations than their closest living ancestors at low altitudes, showing that they were…
higher,
physiologically stressed
There is … … … in Hb between Tibetans living at high altitude and their closest ancestors living at low altitudes
no significant difference
- must be compensating in a different way
The … had higher oxygen saturation than the …, suggesting they were…
Andeans, Tibetans,
less stressed by hypoxia at the same altitude
The altitude study show…
elevation in haemoglobin is not a universal response to high altitude hypoxia
- the Tibetans respond instead by having a higher respiration rate and higher nitric oxide which increases vasodilation
What is the downside to higher erythrocytosis?
Higher Hb leads to more viscous blood, which can put strain on the heart
- a trade-off as it is better for dealing with hypoxia but puts heart at risk
The altitude at response was much lower (1600m compared to ~4000m) for the …
Andeans
- Tibetans required much stronger stimulus
Homeostasis is…
any self-regulating process by which biological systems maintain stability whilst adjusting to variable environmental conditions
- dynamic equilibrium
Internal environment is … not …
stable, static
- continuous change occurs but relatively uniform conditions prevail
Why maintain a steady state?
External environments vary - some external conditions would be lethal to individual cells
- internal processes require certain conditions
- enzymes are often heat-activated
- chemical reaction rates are often temperature dependent
- proteins may denature at very high temperatures
- maintaining concentration gradients
Stimulus –>
receptor –> control centre –> effector
The receptor…
monitors the internal environment
The control centre…
sends a message to the effector (via the nervous or endocrine system) when a parameter exits its normal range
The effector…
re-establishes the internal environment to the set point
Feedback…
returns the output to the input part of the system
In birth, the hormone … stimulates contractions, the contractions themselves stimulate … production, and this is an example of … …
oxytocin, oxytocin, positive feedback
Homeostatic mechanisms are … so are … if not necessary, e.g….
costly, lost,
naked mole rat has lost fur as no need to regulate temperature in stable underground environments
At night, hummingbirds can enter a state of…
torpor - conserve energy as temperature falls to 18-20C (normal 38-40C)
- so can pygmy possums
Pygmy possum body temperature in torpor seemed to…
map onto the ambient temperature as it was changed
Black bears hibernate for …, and their heart rate is … and more …
5-7 months, slower, irregular
Why use performance enhancing drugs (doping)?
- build muscle mass and strength
- increase O2 delivery to exercising tissue
- Mask pain/injury
- decrease weight
- hide use of other drugs
Erythropoietin (EPO) is naturally produced in the body in response to… and causes the bone marrow to..
a reduction in blood oxygen concentration,
release lots of red blood cells with Hb to bring up oxygen saturation
Natural stimuli for erythropoiesis include…
- low atmospheric O2
- exercise
- haemorrhaging
Doping using erythropoietin can increase O2 supply by … but side-effects include…
7-10%,
- Blood thickens
- Heart has to work harder
- increased risk of heart attack/stroke
Meldonium is used to treat
coronary heart disease as it increases blood flow and therefore flow of oxygen
- banned in 2016
- curling dude and maria sharapova
How much do lil rotifers weigh?
0.01 micrograms
How much do phatass blue whales weigh?
100,000 kg
Larger animals experience greater…
gravitational forces
Larger animals have a smaller…
surface area to volume ratio
Larger animals tend to:
- move more slowly
- Have slower digestion rates
- Have slower respiration rates
- Lose heat to the environment less quickly
- Lose water to the environment less quickly
Allometry is..
the study of differential growth
- how body parts or physiological processes scale with body size
Static allometry is when…
body proportions differ between individuals of the same age and sex within a species
Isometric scaling is when…
body proportions stay the same with development (e.g. frogs)
Ontogenetic allometry is when…
body proportions change with development (e.g. humans)
Evolutionary allometry is between…
individuals of different species
When describing allometric relationships, y =
ax^b
y = size of body part x = measure of whole body size a = an initial growth index. Size of y when x=1 b = scaling exponent. Proportional change in y per unit x
If b = 0, size of variable body part is…
unrelated to whole body size - remains exactly the same (not talking about proportion here buddy)
If b = 1, the variable body part scales…
at the same rate as the whole body size (isometric scaling)
if b < 1, the variable body part increases…
slowly relative to body size (negative allometry)
If b > 1, the variable body part increases…
at a faster rate than the whole body size (positive allometry)
Using a log-log scale…
linearises the relationship
For allometric graphs, the units on both axes must…
be the same
Skeletons become…
more robust and larger relative to overall body size as body size increases
Isometric doubling of length will increases surface area … and volume (thus …) …
fourfold, mass, eightfold
- organism has 8x mass to support but area to support weight increases 4x
- organism has 8x metabolically active tissue to support, but respiratory surface areas only increase 4x
Similarly sized endotherms will always have higher … than their ectotherm counterparts
BMRs
(base metabolic rate)
- and unicellular lower than ectotherms
Marine mammals have higher BMRs than … …, which have higher BMRs than …
terrestrial mammals,
marsupials
Metabolic Rate (MR) =
Body weight (W)^0.75
Mass specific MR =
MR/W
therefore
Mass specific MR = W^0.75/W^1 = W^0.75-1 = W^-0.25
Due to the higher SA:V ration, relative to the white rhino the meadow vole has…
- higher heart rate
- higher respiration rate
- higher food intake per gram body weight
If body temperature is too low…
- metabolism slows down
- oxygen supply is inadequate
- cells can freeze (membranes rupture, breakdown of tissue)
If body temperature is too high…
- proteins denature
- oxygen supply in inadequate
- Membrane structure is altered
Heat moves from…
hot areas to cold areas
What is the mammal optimum temperature range?
Lizards?
Insects - some species of butterfly?
36-38C
32-40C
28-39C
Radiation is the transfer of heat, without …, by … …
contact, electromagnetic waves
- accounts for 60% of heat transfer
Conduction is the transfer of heat with…
contact
- accounts for 3% of heat loss
Convection is the movement of….
air/fluid across the body surface
- accounts for 15% of heat loss
Evaporation accounts for…
22% of heat loss
The last form of heat loss is…
respiration
Larger animals lose heat…
less quickly due to the smaller SA:V ratio