Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

SBL Clin > Approach To Malaise And Generalized Pain > Flashcards

Approach To Malaise And Generalized Pain Flashcards

1
Q

What clinical markers are present in Lupus like syndrome/drug-induced

A

+ANA

+Anti histone antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What causes a drug induced SLE?

A 
Sulfa drugs 
Hydralazine
Isoniazid 
Minocycline 
TNF Inhibitors
Quinidine
Chlorpromazine
Methyldopa
Procainamide
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What antibodies is neonatal lupus associated with?

A

Anti Ro or La Abs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the treatment for SLE?

A

Avoid sun
NSAIDS
Corticosteroids
Hydroxychloroquine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What causes mortality in the early years after diagnosis of SLE?

Later years?

A

Infections - opportunistic
Kidney or CNS

Accelerated atherosclerosis - MI
Thromboembolic events

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How do you manage SLE patients?

A

Minimize other conventional risk factors for atherosclerosis
Avoid smoking
Flu vaccines
Pneumococcal vaccines
Cancer screenings (increased risk of malignancy)
Consider avascular necrosis of the bone due to corticosteroid use

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What type of hypersensitivity is SLE?

A

TYPE III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What is the treatment of discoid lupus?

A

Photo protection + topical anti-inflammatory agents of systemic antimalarial drugs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the hallmark of scleroderma?

A

Thickening and hardening of the skin (fibrosis of the skin and visceral organs)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What causes the dry itchy skin in scleroderma?

A

Obliteration of eccrine sweat and sebaceous glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the three forms of scleroderma?

A

Diffuse

Limited (Crest syndrome)

Localized

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a manifestation of limited scleroderma?

A

Pulmonary HTN

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is a manifestation of diffuse scleroderma?

A

Interstitial lung disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does CREST stand for?

A 
Calcinosis cutis 
Raynauds 
Esophageal dysmotility 
Sclerodactylyl 
Telangectasia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Is renal crisis common in limited scleroderma?

A

No

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the primary cause of morbidity and mjortality in scleroderma?

A

Pulmonary disease

Interstitial lung disease seen in diffuse
Pulmonary artery hypertension seen in limited

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

How do you diagnose PAH?

A

A mean pulmonary arterial pressure of 25 mmHG OR GREATER

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

How do you confirm diagnosis of PAH?

A

Right heart catheter

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Which cancer shows an increased incidence in scleroderma?

A

Bronchoalveolar carcinoma

Esophageal adenocarcinoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the diagnostic work up for scleroderma?

A 
Blood pressure 
ESR 
ANA 
UA 
CXR 
Barium swallow 
Echo
PFT 
Skin biopsy 
Serology
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is the serology for Scc (diffuse and limited)?

A

Diffuse - anti Scl 70, anti RNA polymerase III

Limited - +anti centromere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

How do we treat Scc?

A

Treat the symptoms

CCB 
ACE inh 
Anti reflux 
Glucocorticoids 
Cyclophosphamide 
PDE inh
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is an adverse affect of high dose corticosteroids?

A

Renal crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the limited Scc characterized by?

A

Benign skin condition of discreet areas of discolored skin induration

Morphea (patches)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

What are the manifestations of sjogren?

A 
Dry eyes 
Dry mouth 
Vaginal dryness 
Tracheobronchial dryness 
Parotid enlargement
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

What is keratoconjunctivitis sicca?

A

Inadequate tear production causing a foreign body sensation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

What cancer is sjogrens associated with?

A

B Cell NHL (Maltoma)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

What is the serology work up for sjogrens?

A 
\+anti SSA/Ro 
\+anti SSB/La
Low C4 
Hypergammaglobulinemia 
High ESR 
\+RF 
\+ANA
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Treatment of sjogrens?

A

Treat symptoms

Eye lubricants
Frequent water
Hydrdoxychloroquine
Glucocorticoids

Avoid atropine drugs and decongestants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

how do you characterize the muscle involvement in inflammatory myopathies?

A

Symmetrical proximal muscle weakness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

What are the four key skin features of dermatomyositis?

A

Gottron’s patches
Heliotrope rash
Periungual erythema
V neck Erythema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

What is the muscle biopsy finding in dermatomyositis?

A

Perimysial and perivascular inflammation, perifascicular atrophy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

What is seen in labs for Dermatomyositis?

A

Elevated CK and aldolase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

What is seen on serology of dermatomyositis?

A

Anti Jo 1
Anti Mi2
Anti MDA5
Anti P155/P140

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

What malignancies are associated with dermatomyositis?

A 
Ovarian (check CA 125) 
Lung 
Pancreatic 
Stomach 
Colorectal 
NHL
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

What is seen on the biopsy for polymyositis?

A

Endomysial inflammation with invasion of non necrotic muscle fibers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

What is seen on labs for polymyositis?

A

Elevated CK

38
Q

What is seen on serology for polymyositis?

39
Q

What is the treatment for dermatomyositis and polymyositis? **

A

Corticosteroids

40
Q

What is the characteristic muscle weakness in inclusion body myositis?

A

Finger flexion or quadriceps weakness

41
Q

What is seen on biopsy of inclusion body myositis?

A

Endomysial inflammation, rimmed vacuoles, invasion of non necrotic muscle fibers

42
Q

What is seen on labs of IBM?

A

Elevated CK

43
Q

What is seen on serology of IBM?

A

Anti cN1A autoantibodies

44
Q

What is the treatment of IBM?

A

Supportive

45
Q

How do you diagnose Henoch schonlein purpura?

A

IgA deposits on biopsy

46
Q

How do you treat HSP?

A

Glucocorticoids

47
Q

How do you diagnose Goodpastures?

A

Biopsy shows anti basement membrane autoantibodies in basement membrane

48
Q

What causes the hypertension in Takayasu arteritis?

A

Renal artery stenosis

49
Q

How do you diagnose takayasu arteritis?

A

MRI or CT angiography

Biopsy shows granulomas with giant cells

50
Q

How do you treat takayasu arteritis?

A

Glucocorticoids

51
Q

What is the triad in Behcet syndrome?

A

Recurrent mouth ulcers
Genital ulcers
Uveitis

52
Q

What HLA for Behcet syndrome ?

53
Q

What is the treatment of Behcet?

A

Low dose GC

54
Q

What is polyarteritis nodosa characteristically assoc. with?

A

Hep B virus

55
Q

What is seen on biopsy for PAN?

A

FIBRINOID NECROSIS

56
Q

What is seen on serology for PAN?

57
Q

Tx of PAN ?

A

Corticosteroids

58
Q

What do patients die from in Kawasaki disease?

A

Coronary involvement

Aneurysm or MI

59
Q

What is the tx of Kawasaki disease?

A

IVIG and high dose ASA

60
Q

What is seen on serology for Wegeners granulomatosis?

61
Q

What is the hallmark of Wegeners?

A

Granulomatous inflammation

62
Q

What is the tx of Wegeners?

A

Cyclophosphamide and high dose GC or rituximab

63
Q

What are the hallmarks of Churg Strauss syndrome?

A

Asthma + eosinophilia -> vasculitis with granulomas

64
Q

How do you make the diagnosis of Churg Strauss?

65
Q

How do you treat Churg Strauss?

66
Q

Who is affected by Buerger disease?

67
Q

How do you make the diagnosis of Buerger disease?

A

Angiography corkscrew appearance

68
Q

Treatment of Buerger disease?

A

Smoking cessation

69
Q

How does temporal(giant cell) arteritis present?

A

Headache, jaw claudication, visual abnormalities (amaurosis fugax or diplopia)

70
Q

What HLA is associated with temporal arteritis?

71
Q

How do you diagnose temporal arteritis?

A

Temporal artery bx

1.0 cm segment biopsy will show segmental granulomatous vasculitis with multinucleated giant cells

72
Q

How do you treat temporal arteritis?

A

Corticosteroids therapy before biopsy

73
Q

What is polymyalgia rheumatica (PMR) associated with?

A

Temporal/giant cell arteritis

74
Q

How do you diagnose PMR?

A

Elevated ESR and CRP

75
Q

How do you treat PMR?

A

Corticosteroids

76
Q

How do you diagnose secondary raynauds?

A

Nailfold capillaroscopy

77
Q

What serology marker can we use to identify an autoimmune disease?

78
Q

What is the clinically significant ratio of ANA?

79
Q

What are the four ANA patterns?

A

Homogenous
Speckled
Centromere
Nucleolar

80
Q

What staining pattern does CREST show?

A

Centromere pattern

81
Q

Which staining pattern does drug induced SLE show?

A

Homogenous

82
Q

Which staining pattern does Sjögren’s syndrome show?

A

Speckled mostly but can also be homogenous

83
Q

What staining pattern does diffuse systemic sclerosis show?

A

Nucleolar pattern (more than the others) can also be speckled

84
Q

What do the sx of malaise, malar rash, photosensitivity, symmetric inflammatory arthritis, thrombosis, pancytopenia, pericarditis, seizures and psychosis indicate ?

85
Q

Antibodies in SLE include what? (3)

A

ANA, anti-ds DNA, anti Sm (smith)

86
Q

Which antibody present in SLE correlates with disease activity?

A

Anti-ds DNA

87
Q

What happens to complement levels in SLE?

A

Decreased C3 and C4

88
Q

Which type of APA syndrome can cause biological false positive tests for syphilis?

89
Q

Which type of APA syndrome can cause lupus anticoagulant and is a risk factor for venous and arterial thrombosis and miscarriage ?

90
Q

Which type of APA syndrome can cause anti cardiolipin antibodies?

A

Type three

91
Q

What are anti cardiolipin antibodies directed at?

A

Beta 2 GPI

92
Q

What is the treatment for APA syndrome?

A

Anticoagulation

SBL Clin (9 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions