approach to hemaglobinopathies Flashcards
what are the lab findings associated with lead poisoning ?
microcytic hypo chromic anemia
basophilic stippling
increase in ZPP
what is polychromasia ?
increase in reticulocytes which is a sign of hemolysisw
what diseases show spherocytes in peripheral blood smear ?
hereditary spherocytosis
hemolytic anemia ( AIHA warm type )
when do we see schistocytes ?
MAHA
when do we see heinz bodies ?
in G6PD
what differentiates thalassemia from other microcytic anemias ?
increased RBC count in thalassemia
what are the iron studies ?
serum ferritin
TIBC
transferrin saturation
what is thee indication to perform hb electrophoresis and HPLC ?
serum ferritin less than 12 with low iron studies that dont improve with iron therapy
what are the expected findings in electrophoresis of a patient with beta thalassemia major ?
presence of haemoglobin F only and low levels of hba
what type of blood film can we see sickle cells in ?
sickle cells are seen in thin wet blood film sealed with paraffin wax
what is the test for Hb s ?
HB s solubility test
severe anemia at birth is a feature of ?
alpha thalassemia
