Appetite Control Flashcards
Where is the ‘satiety centre’
Arcuate nucleus in hypothalamus
What types of primary neurone are in the arcuate nucleus?
Stimulatory neurones
Inhibitory neurones
What do stimulatory neurones do?
Contain
- neuropeptide Y
- Agouti-related peptide
Promote hunger
What do inhibitory neurones do?
Contain POMC
POMC produces
- α-MSH
- β-endorphin
What is ghrelin?
Hormone produced by stomach when empty
Stimulates excitatory neurones in arcuate nucleus so stimulates appetite
What inhibits ghrelin release?
Filling of stomach
What is PYY?
Peptide tyrosine tyrosine
Released by cells in ileum and colon in response to feeding
Inhibits excitatory neurones in arcuate nucleus so suppresses appetite
What hormones are released by gut to act on hypothalamus?
Ghrelin
PYY
What is leptin?
Hormone released by adipocytes
Suppresses appetite
Action in arcuate nucleus
- stimulate inhibitory neurones
- inhibit excitatory neurones
What effect does insulin have on appetite?
Suppresses appetite
What is amylin?
Hormone produced by β cells in pancreas
Suppresses appetite
What other hormones affect appetite?
GLP-1
Cholecytokinin
Pancreatic polypeptide
