AOB Flashcards

1
Q

MSF crisis Response

A

● Rapid initial assessment
● Measles and other vaccines
● Water and sanitation
● Food and nutrition programs
● Shelters and site planning
● Curative activities
● Control of communicable diseases and epidemics
● Surveillance
● Human resources and training
● Coordination

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1
Q

Katayama fever

A

4-6 weeks post Shisto infection

Rash
Fever
Cough
lymphadenopathy
GI upset

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2
Q

Snail stages Schisto

A

Multiple sporocysts in snail (successive generations)

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3
Q

Epidemiology for strongy

A

Tropics/sub tropics
People who work in rural/agriculture

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4
Q

Give 4 discrete manifestations of Strongy

A
  1. GI - bloating, pain, nausea
  2. Skin - larva currens
  3. Resp - loeflers
  4. Hyperinfection
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5
Q

Epi/incidence malaria

A

250 million cases/year
650, 000 deaths
95% cases and deaths Africa
>80 percent of these in <5

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6
Q

Mosquito stages malaria

A

Gametes taken up
Micro inserts macro (in stomach)
Ookinete
Oocyst
Ruptured Oocyst - sporozoites

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7
Q

Where is Vivax and why?

A

SEA
Americas

Africa largely spared - Duffy negative

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8
Q

Do you get lymphadenopathy in Malara?

A

Rare

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9
Q

Fundoscopy in severe malaria

A

Looking for haemorrhages - white centred retinal haemorrhages

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10
Q

What is the organism which causes Scrub?

A

Orentia Tsutsugamushi

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11
Q

What is the vector for Scrub?

A

Chigger larvae (Leptoromoidum mite)

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12
Q

Incubation period rickettsia infections?

A

5-14 days

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13
Q

Diagnostic testing Scrub?

A

Pathogen detection - PCR

Antibody detection - Indirect immunofluorescent assay (gold standard)

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14
Q

Term used for Acari keeping a pathogen through multiple stages of life

A

Transtadial passage

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15
Q

What group of bacteria is leptospirosis?

A

Spirochetes

Same as syphillis and borrelia (Lyme disease)

16
Q

Incubation period leptospirosis

A

10 days

17
Q

Vector African Trypanosomiasis

A

Tsetse Fly
Glossina sp

18
Q

Infective stage Africa Trypanosomiasis

A

Metacyclic Trypomastigotes

19
Q

Treatment Early stage African Trypanosomiasis

A

Suramin (both Gambians/Rhodiense)

Pentamidine (only gambiense)

20
Q

Late stage treatment African Trypanosomiasis

A

Metarsoprol - rhodiense
NECT/Ethornithine - gambiense

Can use Fexinadozole in the future

21
Q

Treatment Chagas acute phase

A

Nifurtimox
Benzinadazole

Nifty Ben

22
Q

Vector Leishmaniasis

A

Sandfly

Phlebotomus - old world
Lutzimiya - new world

23
Q

Infective stage leishmaniasis

A

Promastigotes

24
Q

Visceral Leish countries 90%

A

Bangladesh
India
Nepal
Sudan
Brazil (NE) expanding urbanisation

25
Q

Main subtypes Leish associated with visceral leishmaniasis

A

L.infantum
L. donovani

26
Q

New world

A

An ageing and unhelpful descriptive term given to the Americas. A leftover term from European exploration and colonialism.

27
Q

Microbiology of rickettsia

A

Obligate intracellula bacteria
It is small
gram -ve

28
Q

What is the pathophysiology of rickettsia?

A

Rickettsial infections cause systemic endothelial infection resulting in lymphohystiolytic vasculutis

29
Q

Vector Onchocerciasis

A

Black fly
(genus Simulium)

30
Q

Causative organism 90% Lymphatic filiarisis

A

Wuchecheria Bancrofti

31
Q

Vector Lymphatic filariasis

A

various mosquitos

32
Q

Epidemiology of loa loa

A

Endemic to sub saharan africa

Think Gabon or Cameroon

33
Q

What are Calabar swellings?

A

Itchy swellings - migratory worms Loa Loa

34
Q

Most common cause eosinophilic meningitis

A

Angiostronglyiasis

Rat lung worm
Ingestion molluscs/salad/veg

35
Q

Live vaccines

A

measles, mumps, rubella,
oral influenza, oral typhoid, oral polio
varicella, shingles,
BCG
yellow fever