Anxiety- Exam 2 Flashcards
Define akathisia
the feeling of not being able to sit still, constantly feeling the urge to move
aka the inability to remain still
What are some defining characteristics of fear?
emotional reaction to a real, external threat perceived as painful, dangerous, or harmful
very specific stimulus and short duration
always gear towards the present
goal is to get away from the threat
What are some defining characteristics of anxiety?
apprehension, nervousness, or dread associated with an anticipated event or an unknown, vague stimulus
nonspecific stimulus
long duration
geared towards the future
the idea of something
When does anxiety become pathologic?
Present without an obvious or reasonable cause
Excessive and out-of-proportion to actual threat
Causes distress, functional impairment, and/or reduced quality of life
name 4 maladaptive congnitions that a person with anxiety might exhibit
Judgement biases
Attentive biases
Avoidant behaviors
Low self-confidence in problem solving skills
_____ are oriented toward identifying how thoughts influence behaviors and perception of outcomes
Cognitive-based therapies (CBT)
_____ exposing patients to anxiety-inducing stimuli in small doses that gradually become more intense
Desensitization
_____ patient observes other individuals who are around anxiety-inducing stimuli
modeling
______ patient is exposed to stimulus that causes anxiety at its worst and made to use relaxation techniques to get through the experience
flooding
Which exposure therapy technique is quicker in the short term but is prone to spontaneous relapses?
flooding
What is the short term/prn therapy for anxiety?
Benzodiazepines (BZDs)
Hydroxyzine
What is the first line treatment for anxiety? second line?
SSRIs, SNRIs
Second-Line - Buspirone, TCAs, BZDs, antipsychotics
_____ MOA enhances the effect of GABA at the GABA receptor
Benzodiazepines
Name some uses of Benzodiazepines
anxiety, panic, insomnia, ETOH withdrawal, agitation, seizures, procedural sedation
Benzos in high doses can cause ____ and _____
amnesia and dissociation
What are the SE of benzos? What are the 2 major ones? A patient is at risk for ____ and _____
*drowsiness, *dizziness, decreased motor coordination, decreased libido, disinhibition, rebound anxiety, amnesia, suicidal ideation
dependence and withdrawal
What are the DDI of benzos? What are the 2 major ones?
*ETOH, *opioids, and other CNS depressants, anticonvulsants, antidepressants, antifungals
What are the CI of benzos?
*pregnancy, BZD allergy, myasthenia gravis, narrow-angle glaucoma
Risk for respiratory depression - COPD, sleep apnea, myasthenia gravis
_____ and _____ are short acting benzos. Which one is IV only? What is the onset?
Midazolam: IV only: 3-5 minutes
Triazolam
What is the indication for Triazolam? What is the onset?
insomnia
15-30 minutes
What are the intermediate acting benzos?
alprazolam
temazepam
oxazepam
lorazepam
clonazepam
_____ has a high abuse potential and possible rebound anxiety. What is the onset? 1/2 life?
alprazolam
15-30 minutes
11-16 hours
What is alprazolam indicated for?
panic, anxiety
What is temazepam indicated for? What is the onset? 1/2 life? Will it show up on a UDS?
insomnia
30-60 minutes
8-15 hours
minimally active metabolite
______ and _____ have no active metabolite
oxazepam and lorazepam
What is oxazepam indicated for? onset? 1/2 life?
insomnia and alcohol withdrawal
60-120 minutes
5-15 hours
What is lorazepam indicated for? onset? 1/2 life?
Anxiety, Seizures, Agitation, ETOH withdrawal, Insomnia, Procedural sedation
30-60 minutes
10-14 hours
What is clonazepam indicated for? onset? 1/2 life?
Panic, Anxiety, Seizures, Tremor
RLS, Insomnia
30-60 minutes
18-39 hours
Of the intermediate acting benzos, _____ has the longest 1/2 life.
Clonazepam (Klonopin)
What are the long acting benzos?
diazepam
chlordiazepoxide
flurazepam
What is the indication of diazepam? onset? 1/2 life?
anxiety, seizures, agitation, alcohol withdrawal, muscle spasms, procedural sedation
30 minutes
**50-100 hours- longer acting
What is the indication of chlordiazepoxide? onset? 1/2 life?
**alcohol withdrawal in the inpt setting
60 minutes
30-100 hours
What is the indication for flurazepam? onset? 1/2 life?
insominia
120 minutes
40-114 hours (up to 160 hours in the elderly)
What are the prescribing cautions with benzos?
PRN only
limited time (1-4 weeks)
have a potential for dependence, tolerance and addiction
avoid use in patients with hx of substance abuse
What is the recommended tapering schedule?
10-25% dose reduction per 1-2 weeks
Slower taper if s/s of withdrawal
Anxiety, dysphoria, tremor, seizures
______ Histamine (H1) receptor antagonist
Anxiolytic, muscle relaxant, antihistamine, antiemetic, sedating
May be helpful in patients with insomnia due to anxiety
hydroxyzine
What are the SE of hydroxyzine?
drowsiness, dizziness, dry mouth, rash, fatigue, respiratory depression
What are the DDI of hydroxyzine?
oral potassium, MAOIs, CNS depressants
Can you give hydroxyzine through an IV? Is it safe in pregnancy?
NO, only approved via PO
DO NOT GIVE in the the first trimester
______ 5HT1a receptor agonist; also acts on dopamine receptors
More effective for cognitive anxiety s/s than somatic s/s
Less anxiolytic effects than BZDs
Buspirone