Antivirals other than retrovirals

Question 1

Antivirals for VZV, HSV

Answer 1

A VALedictorian PENny FAMily Came

Aciclovir
Valaciclovir
Penciclovir
Famciclovir
Cidofovir

Question 2

Antivirals for CMV

Answer 2

Violent Gang Caused Fight

Valganciclovir
Ganciclovir
Cidofovir
Foscarnet

Leflu Let Brin Mari

Leflunamide
Letermovir
Maribavir
Brincidofocir

Question 3

Antivirals for influenzae

Answer 3

wizard of OZ went to PARis and got a cold bal

Oseltamivir
Zanamivir
Peramivir
Amantadine
Rimantadine
Baloxavir marboxil

Question 4

Antivirals for RSV

Answer 4

Ribavirin
Palivizumab

Question 5

MOA and MOR of aciclovir, valaciclovir, penciclovir, famciclovir?

Answer 5

MOA - Nucleoside analogue

MOR
1. Reduced or absent thymidine kinase
2. Altered thymidine kinase activity
3. Altered viral DNA polymerase

Question 6

Which antiviral used to treat aciclovir resistant HSV or VZV infections?

Answer 6

Foscarnet

Question 7

MOA and MOR cidofovir?

Answer 7

MOA - nucleotide analogue

MOR - mutation in the UL45 encoded viral DNA polymerase

Question 8

MOA and MOR ganciclovir and valganciclovir?

Answer 8

MOA - nucleoside analogue

MOR
1. Mutation in the UL97 encoded CMV phosphotransferase - low level resistance to ganciclovir but NOT to foscarnet or cidofovir

2. Mutation in UL54 encoded viral DNA polymerase - high level resistance to ganciclovir and cross resistance to foscarnet or cidofovir

Question 9

MOA and MOR foscarnet?

Answer 9

MOA - pyrophosphate analogue

MOR - Mutation in UL54 encoded viral DNA polymerase

Question 10

MOA and MOR for oseltamivir, zanamivir, peramivir?

Answer 10

MOA - selectively binds to an unoccupied area of viral neuraminidase and inhibits the enzyme, prevents spread of virus in resp tract

MOR - mutation in neuraminidase

MOR Zanamivir - mutation in either neuraminidase or haemagglutinin or both

Question 11

MOA and MOR amantadine and rimantadine?

Answer 11

MOA - only active vs inf A, blocks viral m2 protein ( at low conc - prevents viral uncoating, at high conc - increases lysosomal pH and inhibits virus induced membrane fusion)

MOR
- mutation of m2 protein usually occurs during therapy which can confer cross resistance to rimantadine

Question 12

MOA and MOR ribavirin, S.E, CI?

Answer 12

MOA - guanosine analogue interferes with nucleic acid synthesis - block mRNA production

MOR - not demonstrated

S/E - dose related anemia, marrow suppression at high doses, itch, nausea, depression, cough

C/I - pregnancy (teratogenic) so use contraception for 6 months after therapy for both men and women, condoms (present in semen)

Question 13

Antiviral for life or sight threatening CMV, prevents CMV infection during immunosuppressive therapy after organ transplant?

Answer 13

Ganciclovir

Question 14

Antiviral to treat ganciclovir resistant CMV retinitis?

Answer 14

Foscarnet

Question 15

Antiviral used incase of ganciclovir or foscarnet therapy fail or allergy?

Answer 15

Cidofovir

Question 16

Antiviral used for CMV prophylaxis in patients undergoing hematopoietic stem cell transplantation?

Answer 16

Letermovir