Antifungals

Question 1

Azole drugs?

Answer 1

Fluconazole
Voriconazole
Posiconazole
etc..

Question 2

Echinocandin drugs?

Answer 2

Caspofungin
Micafungin
Aniladulafungin

Question 3

Polenes drugs?

Answer 3

Amph B
Nystatin

Question 4

MOA of azoles?

Answer 4

inhibits cytochrome lanosterol P450 14 alpha demethylase which prevents ergosterol synthesis (an essential component of cell membrane)

Question 5

MOA echinocandins?

Answer 5

Inhibits beta 1,3 D glucan synthase (an essential component of cell wall) which prevents cell wall synthesis

Question 6

MOA polyenes?

Answer 6

2 MOA

1. Disrupts cell membrane by binding to ergosterol which disrupts activity in cell membrane causing leaking of cell content - cell death
2. Oxidative damage to fungal cells (causes oxidative burst - damages fungal cell)

Question 7

MOA fluorouracil (5FU) - flucytosine?

Answer 7

prevents DNA and protein synthesis

Question 8

MOA terbinafine?

Answer 8

inhibits squalene epoxidation preventing formation of ergosterol

Question 9

MOA of ibrexafungerp?

Answer 9

Similar to echinocandins but binding site are different

Question 10

MOA fosmanogepix?

Answer 10

inhibits fungal Gwt1 protein - prevents GPI anchor biosynthesis pathway - affects cell wall integrity

Question 11

MOA griseofulvin

Answer 11

disrupts mitosis by acting on microtubules

Question 12

MOA pentamidine

Answer 12

interacts with DNA, RNA, topoisomerase and ubiquitin

Question 13

Fungus with amphotericin resistance?

Answer 13

Candida lusitinae
Candida guilliermondii
Aspergillus tereus
Scedosporium prolificans
Trichosporon asahii