Antivirals Flashcards
Name all the antiviral drugs
Amantadine Zanamivir Oseltamivir The Clovirs Gancyclovir Foscarnet
MOA of amantadine
blocks viral penetration/uncoating
Clinical use of amantadine/Toxicity and contraindications of amantadine
prophy for influenza A, Parkinsons disease
Ataxia
Dizziness
Slurred speech
A man to dine takes off his coat
No longer effective
MOA of Zanamivir and Oseltamivir
inhibit neuraminidase
Clinical use of zanamivir and oseltamivir/Toxicity and contraindications of zanamivir and oseltramivir
influenza A and B
headache
metallic taste
no alcohol
Name all the “Clovirs”
Acyclovir
Valacyclovir
Famcyclovir
Penciclovir
MOA of clovirs
inhibits DNA polymerase
activated by HSV/VZV thymidine kinase
Clinical use of clovirs/Toxicity and contraindications of clovirs
HSV
VZV
EBV
Well tolerated
crystalline nephropathy if not well hydrated
prophylaxis for immunocompromised
Gancyclovir
Inhibits DNA polymerase
activated by CMV thymidine kinase
Clinical use of gancyclovir/Toxicity and contraindications of gancyclovir
prophy and tx of CMV
Leukopenia
Neutropenia
Thrombocytopenia
Renal toxicity
MOA of Foscarnet
inhibits DNA polymerase
Clinical uses of Foscarnet/Toxicity and contraindications of Foscarnet
CMV Retinitis in immunocompromised
Nephrotoxicity
Use when gancyclovir does not work
