Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Antimicrobials Josi > Antifungals > Flashcards

Antifungals Flashcards

1
Q

Name all the Antifungal drugs

A 
Amphotericin B
Nystatin
Azoles
Flucytosine
Capsofungin
Terbinafine
Griseofulvin
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of Amphotericin B

A

binds ergosterol forms pores in membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Clinical use of Amphotericin B/Toxicity and contraindications of Amphotericin B

A

Systemic and localized candidemia – cocci, crypto, blasto, histo
Aspergillus

Shake and bake (fever and chills)
hypotension
Nephrotoxic

Avoid in pts taking ketoconazole!

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

MOA of Nystatin

A

Binds ergosterol forms pores in the membrane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clinical use of Nystatin/Toxicity and contraindications of Nystatin

A

Oral candidas albicans
Vaginal candidas

Headache
Metallic taste
No alcohol
Too toxic to give orally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name all the Azoles

A 
Fluconazole
Ketoconazole
Clotrimazole
Miconazole
Itraconazole
Voriconazole
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

MOA of azoles

A

Inhibit ergosterol synthesis via CYP450 dependent enzyme lanosterol14alphademethylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Clinical use of azoles/Toxicity and contraindications of azoles

A

Fluconazole: crypto meningitis in AIDs and C. albicans
Ketoconazole: systemic and topical
Clotrimazole/Micon: topical
Vorconizole: aspergillus

Gynecomastis
Hypercortisolism
Liver dysfunction
Fever
Chills

Inhibits CP450

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

MOA of Flucytosine

A

Inhibits DNA and RNA synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clinical use of flucytosine/Toxicity and contraindications of flucytosine

A

Systemic infections

N/V/D, bone marrow suppresion
synergistic with Amphotericin B for crypt meiningitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

MOA of Caspofungin

A

inhibits cell wall synthesis by inhibiting betaglucan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Clinical use of caspofungin/Toxicity and contraindications of caspofungin

A

fungicidal candida spp and invasive apspergillosis

GI upset
Flushing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MOA of Terbinafine

A

inhibits fungal enzyme squalene epoxidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Clinical use of terbinafine/Toxicity and contraindications of terbinafine

A

Dermatophytes, mucocutaneous fungal infections

hepatotoxic
visual disturbances
hematological disorders
cellulitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

MOA of griseofulvin

A

interferes with microtubule function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Clinical use of griseofulvin/Toxicity and contraindications of griseofulvin

A

inhibits growth of dermatophytes

teratogenic
carcinogenic
headaches

induces CYP 450 = warfarin metabolism increases

Antimicrobials Josi (6 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions