Anti-TB Flashcards
Name all the Anti-TB/leprosy antimicrobials
Rifampin Isoniazid Pyrazinamide Ethambutol Streptomycin Bedaquiline Azithromycin Dapsone
Name all the Anti-diarrheal drugs
Rifamixin
Fidaxomicin
Metronidazole
Vancomycin
MOA of Isoniazid
Decrease synthesis of mycolic acid
Must be activated by TB catalase oxidase enzyme
Clinical use of Isoniazid/Toxicity and contraindications of Isoniazid
TB prophylaxis
Neurotoxicity due to B6 deficiency – Vit B6 to prevent neurotoxicity
Hepatotoxic
No alcohol
INH = Injures neurons and hepatocytes
Pyrazinamide
bacteriostatic
Inhibits mycolic acid synthesis
Requires acidic pH to acitvate
Clinical use of pyrazinamide/Toxicity and contraindications of Pyrazinamide
TB
Hepatotoxicity
Gout
Do not use if pregnant
MOA of Ethambutol
Bacteriostatic
Inhibit arbinosol transferase
Clinical use of ethambutol/Toxicity and contraindications of ehtambutol
TB
Ocular toxicity –> blindness
Crosses BBB
MOA of Streptomycin
**in another set of flashcards too
Inhibits 30s subunit
Clinical use of streptomycin/Toxicity and contraindications of Streptomycin
TB
Ototoxic –> deafness
Do not use if pregnant
MOA of Bedaquiline
inhibit mycobacterial ATP synthase
Clinical use of Bedaquiline/Toxicity and contraindications of bedaquiline
TB
N/V, headache, arthralgias
MOA of Azithromycin ** in another set of flashcards too
Inhibit 50s
Clinical use of Azithromycin/Toxicity and contraindications of Azitrhomycin
TB
Prolonged QT, acute cholestatic hepatitis
MOA of Dapsone
inhibits bacterial dihydrofolate synthesis
Clinical use of Dapsone
Leprosy and prophylaxis against pneumocystis jirovecii
MOA of Rifaximin
Inhibits DNA dependent bacterial RNA polymerase
bactericidal
Clinical use of Rifaximin/Toxicity and contraindications of Rifaximin
Travelers diarrhea prophylaxis
bacterial diarrhea, hepatic encephalopathy, Crohn’s disease
Constipation
Metronidazole **in another lecture
GET GAP on the METRO
Vancomycin *** in another lecture
Tx multidrug resistant gram +
Staph aureus
C. diff
