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Antimicrobials Josi > Anti-TB > Flashcards

Anti-TB Flashcards

1
Q

Name all the Anti-TB/leprosy antimicrobials

A 
Rifampin
Isoniazid
Pyrazinamide
Ethambutol
Streptomycin
Bedaquiline
Azithromycin
Dapsone
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2
Q

Name all the Anti-diarrheal drugs

A

Rifamixin
Fidaxomicin
Metronidazole
Vancomycin

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3
Q

MOA of Isoniazid

A

Decrease synthesis of mycolic acid

Must be activated by TB catalase oxidase enzyme

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4
Q

Clinical use of Isoniazid/Toxicity and contraindications of Isoniazid

A

TB prophylaxis

Neurotoxicity due to B6 deficiency – Vit B6 to prevent neurotoxicity
Hepatotoxic
No alcohol

INH = Injures neurons and hepatocytes

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5
Q

Pyrazinamide

A

bacteriostatic
Inhibits mycolic acid synthesis
Requires acidic pH to acitvate

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6
Q

Clinical use of pyrazinamide/Toxicity and contraindications of Pyrazinamide

A

TB

Hepatotoxicity
Gout
Do not use if pregnant

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7
Q

MOA of Ethambutol

A

Bacteriostatic

Inhibit arbinosol transferase

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8
Q

Clinical use of ethambutol/Toxicity and contraindications of ehtambutol

A

TB

Ocular toxicity –> blindness
Crosses BBB

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9
Q

MOA of Streptomycin

**in another set of flashcards too

A

Inhibits 30s subunit

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10
Q

Clinical use of streptomycin/Toxicity and contraindications of Streptomycin

A

TB

Ototoxic –> deafness
Do not use if pregnant

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11
Q

MOA of Bedaquiline

A

inhibit mycobacterial ATP synthase

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12
Q

Clinical use of Bedaquiline/Toxicity and contraindications of bedaquiline

A

TB

N/V, headache, arthralgias

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13
Q

MOA of Azithromycin ** in another set of flashcards too

A

Inhibit 50s

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14
Q

Clinical use of Azithromycin/Toxicity and contraindications of Azitrhomycin

A

TB

Prolonged QT, acute cholestatic hepatitis

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15
Q

MOA of Dapsone

A

inhibits bacterial dihydrofolate synthesis

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16
Q

Clinical use of Dapsone

A

Leprosy and prophylaxis against pneumocystis jirovecii

17
Q

MOA of Rifaximin

A

Inhibits DNA dependent bacterial RNA polymerase

bactericidal

18
Q

Clinical use of Rifaximin/Toxicity and contraindications of Rifaximin

A

Travelers diarrhea prophylaxis
bacterial diarrhea, hepatic encephalopathy, Crohn’s disease

Constipation

19
Q

Metronidazole **in another lecture

A

GET GAP on the METRO

20
Q

Vancomycin *** in another lecture

A

Tx multidrug resistant gram +
Staph aureus
C. diff

Antimicrobials Josi (6 decks)

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