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Antibiotics > Antivirals > Flashcards

Antivirals Flashcards

1
Q

What are examples of neuraminidase inhibitors?

A

Oseltamivir
Zanamivir
Adamantane (amantadine, rimantadine)

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2
Q

When should NA inhibitors be used?

A

Early on…works against dividing virus

Can be used prophylactically…but vaccine is better

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3
Q

When are adamantanes used?

A

Parkinson Disease

Change in viral M2 proton ion channel –> resistance

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4
Q

What is antigenic shift?

A

Gene reassortment –>altered surface proteins/antigenic profile

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5
Q

What is antigenic drift?

A

Small gene mutations/changes –> altered Ab-binding sites and escape from immunity

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6
Q

How old should a patient be to be given oseltamivir?

A

> 1yo

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7
Q

What activates the prodrug oseltamivir?

A

Hepatic esterases

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8
Q

Where is oseltamivir excreted?

A

Kidney…modify dose for renal insufficiency

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9
Q

What are the side effects of oseltamivir?

A

GI
Headache
Fatigue

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10
Q

How old should a patient be to be given zanamivir?

A

> 7yo

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11
Q

Patients with what kind of diseases should not be given zanamivir?

A

Respiratory diseases

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Antibiotics (4 decks)

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