Antiviral drugs

Question 1

Name the two types of viruses

Answer 1

Nonenveloped and enveloped

Question 2

Name the 4 types of antiviral drug classes we are responsable for

Answer 2

NRTIs/NtRTIs
NNRTIs
Integrase Inhibitors
Protease Inhibitors

Question 3

True/False? HIV is an enveloped virus

Answer 3

True

Question 4

What are 2 types of drugs against HIV?

Answer 4

NRTIs/NNRTIs

Protease inhibitors

Question 5

True/False? There is a cure for HIV

Answer 5

False

We can only prevent it as best we can

Question 6

What is Zidovudine (AZT) and how does it work?

Answer 6

Nucleoside Reverse Transcriptase Inhibitor:

Analog of Thymidine, terminates elongation, can’t be concatenated
AND
competitive inhibitor of RTase

Question 7

What is Lamivudine (3TC) and how does it work?

Answer 7

Analogue of Deoxycytidine, ends synthesis early

fewer side effects than AZT

Question 8

What is Tenofovir and how does it work?

Answer 8

NtRTI: Analog of AMP, inhibits reverse transcriptase

Question 9

How many phosphate units does Tenofovir diphosphate have?

Answer 9

Three (analog of ATP)

Question 10

How do integrase inhibitors work?

Answer 10

We don’t need to know

Question 11

How does HIV protease work?

Answer 11

Homodimerizes, cleaves GagPol

Question 12

What are the 2 proteins expressed on Viral envelopes?

Answer 12

Neuraminidase

Hemagglutinin

Question 13

How does influenza virus enter cells?

Answer 13

Hemagglutinin binds sialic acids on cell membrane

Question 14

How does influenza virus leave cells?

Answer 14

Neuraminidase cleaves sialic acid receptor

Question 15

What are 3 types of Nucleoside Reverse-Transcriptase Inhibitor?

Answer 15

Zidovudine, Lamivudine, Tenofovir

Question 16

What are two types of NNRTIs?

Answer 16

EtraviRINE

PilpivirINE

Question 17

What are two Integrase inhibitors?

Answer 17

DoluteGRAVIR

BicteGRAVIR

Question 18

What are two protease inhibitors?

Answer 18

LopiNAVIR

RitoNAVIR