Antiprotozoal Drugs Flashcards
1
Q
What is Hemozoin?
A
A byproduct of heme digestion by malaria, insoluble non-toxic crystals
2
Q
What do Quinine and Chloroquine do?
A
(tonic water)
Accumulate in digestive vesicles of Plasmodium and inhibit heme polymerase (prevents hemozoin formation)
3
Q
What is artesunate?
A
Semisynthetic prodrug, interferes with hemoglobin metabolism by producing free radicals
4
Q
Which two antibacterial drugs can be used as antimalarial drugs?
A
Doxycycline (tetracycline)
azithromycin (macrolide)
They target ribosomes within parasite mitochondria
(can also affect human mitochondria)
5
Q
What are the two stages of malaria’s life cycle, and where is each cycle located in its host(s)?
A
Asexual reproductive phase: human liver blood cells
Sexual phase:
mosquito salivary glands/gut
