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Phar 301 > Antifungal Drugs > Flashcards

Antifungal Drugs Flashcards

1
Q

Name the 2 types of antifungal agents we’re responsible to know

A

Amphotericin B

Azoles

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2
Q

How does Amphotericin B work?

A

Polyene

Binds ergosterol and forms a pore in fungus cell wall (injected as liposome)

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3
Q

Name two Types of azole and two examples of each

A

Triazole:
Fluconazole
Voriconazole

Imidazole:
Miconazole
Ketoconazole (racemate)

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4
Q

What is AmBisome®?

A

Liposomal amphotericin B

Lipid formulation of AB with significantly improved toxicity profile

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5
Q

What do the Azoles do?

A

Inhibit fungal cell membrane

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Phar 301 (23 decks)

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