Antiulcer Meds

Question 1

If someone has H.pylori, we should give them what kind of medications?

Answer 1

Antibiotics

Question 2

Proton Pump Inhibitors (PPI) are the____________?

Answer 2

• The most powerful Antiulcer medications.

Question 3

What is the best time to take Proton Pump Inhibitors (PPI)?

Answer 3

• Morning before breakfast.

(Because stomach acid destroys PPI)

Question 4

Stomach ulcer pain occurs ___________?

Answer 4

After eating food.

Question 5

Duodenum ulcer pain occurs ___________?

Answer 5

On an empty stomach.

Question 6

Risk factors of Peptic ulcer disease (PUD).

Answer 6

• Stress
• Tobacco use
• Alcohol use
• Some medications (NSAIDs, etc)

Question 7

Signs and symptoms of Peptic ulcer disease (PUD).

Answer 7

• Stomach pain
• Loss of appetite
• Feeling bloated
• Nausea
• Vomiting
• Foul-smelling black stool (Melena) - (if bleeding occurs)

Question 8

What is the cause of Peptic ulcer disease (PUD).

Answer 8

H.pylori

(Helicobacter Pylori)

Question 9

How do we treat Peptic ulcer disease (PUD)?

Answer 9

• By treating the underlying cause:-
  * By stopping the NSAID use.
  *By starting the Antibiotics for H.pylori.
• By prescribing meds that will reduce the stomach acid secretion to:-
  * Promote healing.
  * Prevent further damage.

Question 10

Examples of Antisecretory agents?

Answer 10

• Histamine-2 (H2) blockers.
• Proton Pump Inhibitors (PPI).

Question 11

Examples of the Histamine-2 (H2) blockers.

Answer 11

(They end with “tidine”)

• Famotidine
• Ranitidine

Question 12

Facts about Histamine-2 (H2) blockers?

Answer 12

• They are given to prevent stomach ulcers when taking NSAIDs.
• They are used in Anaphylactic reaction.
• Its also given to ICU patients to prevent stomach ulcers.
• They treat various conditions, such as:- (PIGS)
  * Peptic ulcer disease (PUD)
  * Indigestion
  * GERD
  * Stress ulcer prophylaxis

Question 13

High yield concepts of Histamine-2 (H2) blockers?

Answer 13

• Available over-the-counter.
• Well tolerated.

Question 14

Examples of the Proton Pump Inhibitors (PPI).

Answer 14

(They end with “prazole”)

• Esomeprazole
• Lansoprazole
• Omeprazole
• Pantoprazole

Question 15

Facts about Proton Pump Inhibitors (PPI)?

Answer 15

• Don’t crush or chew.
• They have a short half-life.
• They should be taken in the morning before breakfast.

Question 16

High yield concepts of Proton Pump Inhibitors?

Answer 16

• Well tolerated.
• Time of dosing - (taken in the morning before breakfast).
• Infection risk - (can cause Pneumonia & C.diff)