Antitumor Antibiotics Flashcards
0
Q
Antracyclins
A
Cerubidine Adriamycin/ Doxil Idamycin Novantrone Valstar
1
Q
Intercalate b/t nucleic acids = DNA breakage
A
Anthracyclines
2
Q
Valstar
A
Valrubicin
3
Q
Novantrone
A
Mitoxantrone
4
Q
Adriamycin
A
Doxorubicin
5
Q
Doxil
A
Liposomal doxorubicin
6
Q
Cerubidine
A
Daunorubicin
7
Q
Idamycin
A
Idrarubicin
8
Q
Are there any oral formulations of anti tumor antibiotics?
A
No
9
Q
What is the life time max of Adriamycin or Doxil?
A
500mg/meter squared
10
Q
What is the life time max of Cerubidine?
A
900mg/meter squared
11
Q
What is the life time max of Novantrone
A
140mg/meter squared
12
Q
What is side for cardioprotection with Adriamycin/Doxil?
When should it be used?
A
Zinecard (dexrazoxane)
If doxorubicin dose is to exceed 300mg/meter squared
13
Q
What color does Mitoxantrone turn bodily fluids
A
Blue
14
Q
Inhibit synthesis in M &G2 phase
A
Streptomyces
