Antimetabolites

Question 0

Mitotic phase

Answer 0

S phase specific

Question 1

MOA

Answer 1

Replace natural nucleic acid bases

Question 2

Pyrimidine antagonist

Answer 2

Adrucil
Xeloda
Gemzar

Question 3

Topical 5-fluorouracil

Answer 3

Efudex

Carac

Question 4

Contraindication for 5-fluorouracil

Answer 4

CrCl<30

Question 5

Adrucil

Answer 5

5-FU

Question 6

Xeloda

Answer 6

Capecitabine

Question 7

Gemzar

Answer 7

Gemcitabine

Question 8

Folate antagonist

Answer 8

Methotrexate

Question 9

What lowers MTX toxicity

Answer 9

Leucovorin

Question 10

What can increase MTX levels

Answer 10

NSAIDS

Probenacid

Question 11

Purine antagonist

Answer 11

Ara-c

Purinethol

Question 12

Purinethol

Answer 12

6-mercaptopurine

Question 13

Ara-c

Answer 13

Cytarabine

Question 14

Oral formulations

Answer 14

Adrucil
Xeloda
Purinethol
Methotrexate ( this is the only medication that is also IV, IM,SQ,IT,IA)

Question 15

Why are high doses of MTX used

Answer 15

BBB penetration and overcome resistance

Question 16

What pharmacogenomic testing is recommended for Purinethol to avoid toxicity

Answer 16

TPMT

Question 17

Why is leucovorin given with 5-FU?

Answer 17

Increase the efficiency

Question 18

Xeloda is a pro drug of

Answer 18

5-FU

Question 19

Should Xeloda be taken with meals or without?

Answer 19

With meals

Question 20

Xeloda contraindications

Answer 20

Known DPD deficiency

CrCl<30

Question 21

Which antimetabolite may cause flu like symptoms within 24 hours of administration?

What is used to manage symptoms?

Answer 21

Gemzar

Tylenol