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Chemotherapy > Antimetabolites > Flashcards

Antimetabolites Flashcards

0
Q

Mitotic phase

A

S phase specific

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1
Q

MOA

A

Replace natural nucleic acid bases

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2
Q

Pyrimidine antagonist

A

Adrucil
Xeloda
Gemzar

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3
Q

Topical 5-fluorouracil

A

Efudex

Carac

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4
Q

Contraindication for 5-fluorouracil

A

CrCl<30

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5
Q

Adrucil

A

5-FU

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6
Q

Xeloda

A

Capecitabine

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7
Q

Gemzar

A

Gemcitabine

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8
Q

Folate antagonist

A

Methotrexate

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9
Q

What lowers MTX toxicity

A

Leucovorin

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10
Q

What can increase MTX levels

A

NSAIDS

Probenacid

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11
Q

Purine antagonist

A

Ara-c

Purinethol

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12
Q

Purinethol

A

6-mercaptopurine

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13
Q

Ara-c

A

Cytarabine

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14
Q

Oral formulations

A

Adrucil
Xeloda
Purinethol
Methotrexate ( this is the only medication that is also IV, IM,SQ,IT,IA)

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15
Q

Why are high doses of MTX used

A

BBB penetration and overcome resistance

16
Q

What pharmacogenomic testing is recommended for Purinethol to avoid toxicity

A

TPMT

17
Q

Why is leucovorin given with 5-FU?

A

Increase the efficiency

18
Q

Xeloda is a pro drug of

A

5-FU

19
Q

Should Xeloda be taken with meals or without?

A

With meals

20
Q

Xeloda contraindications

A

Known DPD deficiency

CrCl<30

21
Q

Which antimetabolite may cause flu like symptoms within 24 hours of administration?

What is used to manage symptoms?

A

Gemzar

Tylenol

Chemotherapy (7 decks)

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