Antipsychotics: FGAs

Question 1

Common uses of FGAs

Answer 1

Schizophrenia
Agitation/ aggression
Nausea and vomiting
Intractable hiccups

Question 2

Common FGAs

Answer 2

Haloperidol

Chlorpromazine

Question 3

In order for something to be considered a mental disorder, what four aspects must be present?

Answer 3

1. Distress
2. Danger
3. Deviance
4. Dysfunction

Question 4

Positive Schizophrenia Symptoms

Answer 4

Hallucinations
Delusions
Disorganzied speech
Bizarre behavior

Question 5

Negative Schizophrenia Symptoms

Answer 5

Affective flattening (lack of expression)
Alogia (lack speech)
Avolition (lack of motivation)
Anhedonia (lack of pleasure) 
Social isolation

Question 6

How do FGAs work?

Answer 6

FGAs block dopamine receptors in the brain.

Question 7

What is the problem with FGAs?

Answer 7

The dopamine pathways are needed to go to the mesolimbic system, but FGAs also travel to the mesocortical, nigrostriatal, and tuberoinfundibular.

Question 8

Major side effects of FGAs

Answer 8

Anticholinergic effects
Orthostatic hypotension
Sedation
Neuroendocrine effects
Photosensitivity

Question 9

Extrapyramidal symptoms of FGAs

Answer 9

Acute dystonia
Akathisia
Parkonsonism
Tardive dyskinesia

Question 10

Neuroleptic Malignant Syndrome

Answer 10

Fever
Elevated WBCs and CPK
Vital signs unstable
Encephalopathy
Rigidity

Question 11

Dopamine Pathways FGAs travel to

Answer 11

Mesolimbic (decreases positive symptoms in Schiz)
Mesocortical (makes negative symptoms worse)
Nigrostriatal (causes EPS symptoms)
Tuberoinfundibular (causes endocrine problems)

Only want the drugs to go to mesolimbic