Antipsychotics Flashcards
After starting an antipsychotic medication, what EPS side effects might we observe after hours to days?
Acute Dystonia (oculogyric crisis, tongue protrusion, torticollis)
After starting an antipsychotic medication, what EPS side effects might we observe after days to weeks?
Pseudoparkinsonism and akathisia
After starting an antipsychotic medication, what EPS side effects might we observe after months to years?
Tardive Dyskinesia
How do we treat acute dystonia, akathisia, and pseudoparkinsonism?
Treat with an anticholinergic like benztropine or diphen hydramine
We see pseudoparkinsonism as a side effect of what drugs?
first gen antipsychotics, metoclopramide, and valproate
Dyskinesia arises from inhibition of the _________________ tract.
nigrostriatal
Too much dopamine in the nigrostriatal tract results in ______________ and too little results in_____________________
psychosis and parkinsonism
For chronic noncompliance, what drug forms can we consider?
IM! depot olanzapine is good for homeless and pschotic pts with noncompliance issues.
Benztroping leads to releif of parkinsonism by targeting
acetylcholine, benztropine is an acetycholine antagonist.
Pramipexole versus antipsychotics
Pramipexole= dopamine AGONIST to treat parkinsons
Antipsychotics= dopamine ANTAGONISTS
Beta blockers target what?
Beta adrenergic receptors and can be thought of as a norepi antagonist
How might pramipexole lead to psychotic features?
Pramipexole is not an antipsychotic. It is a dopamine agonist to help treat parkinsons. This drug works by increasing dopamine in the dorsal striatum. This drug can impact the ventral striatum which may lead to mood dysregulation.
Increased Dopamine concentrations in the limbic system will lead to psychotic features!!!!!
