Antipsychotic/ Antidepressants

Question 1

1. Which of the following is a prototype of atypical antipsychotic drug?
   a. Chlorpromazine
   b. Thioridazine
   c. Risperidone
   d. Clozapine

Answer 1

d. Clozapine

A & B: typical antipsychotic drug
C: atypical, but NOT the prototype

Question 2

2. Side Effects include anti-cholinergic, anti-adrenergic & extrapyramidal
   a. Haloperidol
   b. Lithium
   c. Clozapine
   d. Carbamazepine

Answer 2

a. Haloperidol - extrapyramidal dysfunction is major adverse effect.

Question 3

Neurological side effects, inc extrapyramidal reactions; also, anticholinergic properties (dry mouth) and antiadrenergic effects (orthostatic hypotension)

Answer 3

Haloperidol

Question 4

Neuromuscular effects (tremors, ataxia), endocrine (hypothyroidism), arrhythmia, allergic reactions

Answer 4

Lithium

Question 5

SE: Agranulocytosis

Answer 5

Clozapine

Question 6

SE: sedation, no EPS

Answer 6

Carbamazepine

Question 7

3. Accepted 1st alternative for treating patients with bipolar disorder not adequately responsive to lithium

Answer 7

Carbamazepine

Question 8

1st line tx for mania

Answer 8

Valproid Acid

Question 9

Tx for Schizophrenia

Answer 9

Chlorpromazine

Question 10

4. Butyrophenone antipsyhotic

Answer 10

Haloperidol

Question 11

Aliphatic Phenothiazine Derivative

Answer 11

Thioridazine

Chlorpromazine

Question 12

Thioxanthene Derivative

Answer 12

Thiothixine

Question 13

Piperazine Phenothiazine Derivative

Answer 13

Fluphenazine

Question 14

5. An example of atypical antipsychotic agent:
   a. thioridazine
   b. thiothixine
   c. risperidone
   d. chlorpromazine

Answer 14

c. risperidone

• thioridazine is an Aliphatic Phenothiazine Derivative (typical)
• thiothixine is a Thioxanthene Derivative (typical)
• chlorpromazine - Aliphatic Phenothiazine Derivative (typical)