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Y2 Pharmacology > Antihypertensives > Flashcards

Antihypertensives Flashcards

1
Q

This drug acts on the vasomotor center

A

METHYLDOPA
and Clonidine

Sympathoplegics (Centrally-Acting)

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2
Q

Acts on the vascular smooth muscle

A

Hydralazine

vasodilator

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3
Q

AliskeREN

A

Direcet RENin Inhibitor

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4
Q

Captopril

A

ACE Inhibitor

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5
Q

Losartan

A

ARB

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6
Q

Hydrochlorothiazide

A

Diuretics. Thiazide.

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7
Q

Direct Renin Inhibitor

A

Aliskeren

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8
Q

Benzothiazepine calcium channel blocker

A

diltiazem

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9
Q

NOT a vasodilator

a. hydralazine
b. minoxidil
c. diazoxide
d. methyldopa

A

methydopa

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10
Q

All BUT one is not a parenteral vasodilator agents

a. amlodipine
b. Na nitroprusside
c. fenoldepam
d. labetalol

A

a. amlodipine

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11
Q

selective beta blocker that stimulates the

RELEASE OF NO CAUSING VASODILATION

A

Nevibolol

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12
Q

NON SELECTIVE beta blocker

A

Propranolol

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13
Q

DOC for

uncontrolled hypertension and recurrent bipedal edema and orthopnea

A

hydrochlorothiazide

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14
Q

DOC for

hypertension and DIABETES

A

valsartan

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15
Q

DOC for

hypertension and ANGINA

A

nevibolol

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16
Q

DOC for
hypertension, atrial fibrillation (S/Sx ng thyrotoxicosis)
and THYROTOXICOSIS

A

Propranolol

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17
Q

DOC for

buntis with hypertensive

A

Methyldopa

and Clonidine

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18
Q

blocks Na/Cl transporter in the

DISTAL convoluted tubule

A

thiazide

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19
Q

blocks Na/Cl transporter in the

COLLECTING tubule

A

Spirinolactone

20
Q

blocks Na/Cl transporter in the

PROXIMAL convoluted tubule

A

Acetazolamide

21
Q

blocks Na/Cl transporter in the

renal LOOP OF HENLE

A

Furosemide

22
Q

blocks vesicular amine transporter in noradrenergic nerves and depletes transmitter stores

A

reserpine

and guanethidine

23
Q

Selectively blocks apha-1 adrenoceptors

A

Prazosin,

saka Terazosin, Doxazosin

24
Q

most common side effect of ACE inhibitors

A

cough

25
Q

teratogenicity is NOT a side effect of

A

Clonidine

…saka methyldopa

26
Q

Angioedema is NOT seen as a side effect of

A

Thiazide

27
Q

Angioedema is seen as a side effect of

A

Amlodipine
Lisinopril
Nifedipine

28
Q

Side effect: Hypertrichosis

A

Minoxidil

29
Q

Side effect: Hemolytic anemia

A

Methyldopa

30
Q

Severe neutropenia or proteinuria if given in high doses in patients with renal insufficiency

A

Captopril

31
Q

should not be combined with ARBs

A

Lisinopril (ACE inhibitors)

32
Q

should not be given to patient with hypertension having bronchial asthma

A

Propanolol (kasi non-selective, need ng asthmatic ng B2 agonist)

33
Q

Contraindication: heart block

A

Metoprolol

34
Q

Contraindication: Glaucoma

A

Fenoldepam (increases intraocular pressure)

35
Q

Diuretics

A

Thiazides: Hydrochlorothiazide, Chlorthalidone
Loop diuretics: Furosemide
Spironolactone, Eplerenone

36
Q

Potassium-sparing diuretics:

Diuretic with increased Na and decresed K excretion

A

Spirinolactone
saka Amiloride

also, Epleneron and Triamterene

37
Q

Potassium-sparing diuretics contraindicated in patients with:

A

renal insufficiency

38
Q

Only THIAZIDE available for PARENTERAL administration

A

Chlorothiazide

39
Q

Diuretic. side effectL Ototoxicity

A

Loop diuretic (Furosemide)

40
Q

competitive inhibitor of RENin

A

aliskiREN

41
Q

Clonidine side effect:

A

sedation

42
Q

activate alpha-2 adrenoceptors

A

Clonidine,

methyldopa

43
Q

vasodilators

A 
hydralazine,
minoxidil
diazoxide (parenteral agent)
verapamil
diltiazem
mifedipine
amlodipine
fenoldopam (parenteral agent)
nitroprusside (parenteral agent)
labetalol (parenteral agent)
44
Q

parenteral vasodilator agents

A

diazoxide (parenteral agent)
fenoldopam (parenteral agent)
nitroprusside (parenteral agent)
labetalol (parenteral agent)

45
Q

very widely used Beta-1 selective blockers

A

Metoprolol

Atenolol

46
Q

Also treats hair loss

A

Minoxidil

47
Q

Hydralazine side effect:

A

Lupus-like syndrome, angina, tachydardia

Y2 Pharmacology (11 decks)

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