Antipsychotic Agents Flashcards
Antipsychotic ACTION
block postsynaptic dopamine receptors
inhibit dopamine-mediated transmission of neural impulses
Antipsychotic INDICATIONS
schizo
bipolar mania
antiemetics
intractable hiccoughs
Conventional/typical/1st gen medicines
Phenothiazines (thorazine, Prolixin)
Thioxanthenes (Navane)
Dibenzoxazepnes (Loxitane)
Haloperidol (HALDOL)
Antipsychotic CONTRA
comatose CNS depression blood dyscrasias parkinsons glaucoma dementia related
Antipsychotic PRECAUTIONS
elderly
severely ill
diabetic
respiratory insufficiency
Positive symptoms of psychosis examples
hallucinations / delusions
1st Gen agents for positive symptoms of Schizo
chlorpromazine (Thorazine)
fluphenazine (Prolixin)
haloperidol (Haldol)
Extrapyramidal Side Effects - EPS (b/c of 1st gen meds)
dystonia
akathisia
tardive dyskinesia
drug induced parkinsonism
dystonia
muscle stiffness
robotic movement
akathisia
restlessness
constant movement
unable to sit
tardive dyskinesia
abnormal jaw, neck, trapezoid movement
Adverse Drug Reactions of 1st gen meds
neuroleptic malignant syndrome (NMS)
NMS symptoms (ICU needed)
severe muscle rigidity high fever tachycardia BP fluctuation diaphoresis lowered mental status (coma and stupor)
NMS treatment
dantrolene and cooling blankets
Atypical / 2nd Generation meds action
weaker dopamine receptor agonists can address (+) or (-) symptoms
2nd Generation CONTRA
coma
severely depressed
dementia related psychosis
hx of QT prolongation / cardiac issues
2nd Generation PRECAUTIONS
elderly
hx seizures
diabetes (metabolic syndrome)
pregnant clients (cross over to fetus)
Anticholinergic toxicity effects
dry mouth distended bladder tachycardia altered mental status HTN mydrias
Antipsychotic Planning/Implementation
monitor client for what?
anticholinergic effects PHOTOSENSITIVITY EKG changes reduction of seizure threshold agranulocytosis (clozapine) metabolic syndrome
